Clonidine Impurity 1 CAS 21709-18-2
| CAS No. | 21709-18-2 |
| Molecular Formula | C7H3Cl4N |
| Molecular Weight | 242.92 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 242.92 g/mol gives Clonidine Impurity 1 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Clonidine Impurity 1 (CAS 21709-18-2, C7H3Cl4N) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Clonidine Impurity 1 (C7H3Cl4N) contains a nitrile group, chlorine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 5.0, corresponding to approximately 5 ring(s) or double-bond equivalent(s). With a molecular weight of 242.92 g/mol, it falls into the medium-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Clonidine Impurity 1 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H3Cl4N |
| Molecular Weight | 242.92 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1963 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Clonidine Standards
Recommended Standards
- 4,5-Dibromo-1,3-thiazole (CAS 67594-67-6)
- 2,3-Dibromopyridine (CAS 13534-89-9)
- 3-Bromo-2,4,6-trimethylphenylboronic acid (CAS 849062-19-7)
- 2,5-Dibromopiperidine (CAS 916792-55-7)
- Canagliflozin Impurity 19 (CAS 2110533-80-5)
- Piracetam Impurity 11 (CAS 598-41-4)
- Levocarnitine Impurity 18 (CAS 84367-31-7)
- 4-chloroquinazolin-6-ol (CAS 848438-50-6)
- 2-Chloro-N-(5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl)acetamide (CAS 42458-71-9)
- 2-Quinolinecarboxylic acid, 6,8-dichloro- (CAS 38501-05-2)
- 4-(4-Chloro-3,5-dimethylphenoxy)-2-(trifluoromethyl)aniline (CAS 946698-24-4)
- 1-(2-Fluoro-ethyl)-3-methyl-4-nitro-1h-pyrazole (CAS 1443279-36-4)
- 2-(azetidin-3-yl)acetonitrile hydrochloride (CAS 1423057-36-6)
- Insulin B (22-25) (CAS 34367-73-2)
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