5-[4-(Trifluoromethoxy)phenyl]pyrimidin-2-amine CAS 1111105-03-3
| CAS No. | 1111105-03-3 |
| Molecular Formula | C11H8F3N3O |
| Molecular Weight | 255.20 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 5-[4-(Trifluoromethoxy)phenyl]pyrimidin-2-amine (C11H8F3N3O) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
CATO supplies 5-[4-(Trifluoromethoxy)phenyl]pyrimidin-2-amine (CAS 1111105-03-3), a certified reference material (molecular formula C11H8F3N3O, MW 255.20 g/mol) for analytical method development and quality control.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 5-[4-(Trifluoromethoxy)phenyl]pyrimidin-2-amine under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C11H8F3N3O |
| Molecular Weight | 255.20 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Trifluoromethoxy Standards
- 5-(3-(Trifluoromethoxy)phenyl)pyrimidin-2-amine (CAS 1111112-25-4)
- 4-(4-(Trifluoromethoxy)phenyl)pyrimidin-2-amine (CAS 874779-70-1)
- 5-(3-(Trifluoromethoxy)phenyl)pyridin-3-ol (CAS 1258626-06-0)
- 6-(4-(Trifluoromethoxy)phenyl)pyridin-3-ol, 97% (CAS 1261729-36-5)
- 3-Oxo-1-[4-(trifluoromethoxy)phenyl]cyclobutanecarbonitrile (CAS 1432048-72-0)
- 3-Oxo-1-(3-(trifluoromethoxy)phenyl)cyclobutanecarbonitrile (CAS 1432050-58-2)
- 1-(4-(Trifluoromethoxy)phenyl)-1H-pyrrole-2-carbaldehyde (CAS 260442-97-5)
- 1-(4-(Trifluoromethoxy)phenyl)-1H-pyrrole-3-carbaldehyde (CAS 439094-17-4)
Recommended Standards
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- 2-Acetamido-3-(methylamino)propanoic acid (CAS 119945-11-8)
- 5,6-Dihydroxy-2-phenyl-4H-chromen-4-one (CAS 6665-66-3)
- (4-Methoxy-3,5-dimethylphenyl)(thiophen-2-yl)methanol (CAS 1443305-70-1)
- 2,4-Dibromo-1-(2-bromoethoxy)benzene (CAS 76429-66-8)
- N-(4-benzamidobutyl)benzamide (CAS 31991-78-3)
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- 2-Amino-2-methyl-N-propylpropanamide hydrochloride (CAS 1219957-29-5)
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Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com