5-(3-(Trifluoromethoxy)phenyl)pyrimidin-2-amine CAS 1111112-25-4
| CAS No. | 1111112-25-4 |
| Molecular Formula | C11H8F3N3O |
| Molecular Weight | 255.20 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
5-(3-(Trifluoromethoxy)phenyl)pyrimidin-2-amine (CAS 1111112-25-4), molecular formula C11H8F3N3O and molecular weight 255.20 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution, 5-(3-(Trifluoromethoxy)phenyl)pyrimidin-2-amine is typically pale yellow to yellow low-melting solid. Its solid-state physicochemical attributes — including a molecular weight of 255.20 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H8F3N3O |
| Molecular Weight | 255.20 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Trifluoromethoxy Standards
- 5-[4-(Trifluoromethoxy)phenyl]pyrimidin-2-amine (CAS 1111105-03-3)
- 4-(4-(Trifluoromethoxy)phenyl)pyrimidin-2-amine (CAS 874779-70-1)
- 5-(3-(Trifluoromethoxy)phenyl)pyridin-3-ol (CAS 1258626-06-0)
- 6-(4-(Trifluoromethoxy)phenyl)pyridin-3-ol, 97% (CAS 1261729-36-5)
- 3-Oxo-1-[4-(trifluoromethoxy)phenyl]cyclobutanecarbonitrile (CAS 1432048-72-0)
- 3-Oxo-1-(3-(trifluoromethoxy)phenyl)cyclobutanecarbonitrile (CAS 1432050-58-2)
- 1-(4-(Trifluoromethoxy)phenyl)-1H-pyrrole-2-carbaldehyde (CAS 260442-97-5)
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Recommended Standards
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- 2-(Trifluoromethyl)quinoline-4-carbohydrazide, 97% (CAS 1185292-58-3)
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- 2-(4-(5-Bromopyridin-2-yl)piperazin-1-yl)ethyl acetate (CAS 1823184-03-7)
- 1-(4-Chloro-2-nitrophenyl)-2,2,2-trifluoroethanol (CAS 2228945-51-3)
- 2-(4-Cyano-2-ethoxyphenoxy)acetamide (CAS 902094-95-5)
- (R)-2-Bromo-1-(4-fluorophenyl)ethanol (CAS 1097211-38-5)
- (E)-(2-Nitrovinyl)cyclopropane (CAS 1175052-41-1)
- 3-(2-Bromoethyl)-6-methylpyrimidin-4(3h)-one (CAS 1250208-66-2)
- 3-Methyl-5-(2-methyl-pyrrolidin-2-yl)-[1,2,4]oxadiazole hydrochloride (CAS 1361116-14-4)
- Insulin Glargine (CAS 160337-95-1)
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