Iopromide Impurity 9 CAS 111453-32-8
| CAS No. | 111453-32-8 |
| Molecular Formula | C11H11I3N2O5 |
| Molecular Weight | 631.93 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 631.93 g/mol gives Iopromide Impurity 9 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Iopromide Impurity 9 (CAS 111453-32-8, C11H11I3N2O5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Iopromide Impurity 9 (C11H11I3N2O5) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, iodine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H11I3N2O5 |
| Molecular Weight | 631.93 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Halogen Content | I-containing |
| Nitrogen Atoms | 2 |
Related Iopromide Standards
- Iopromide Impurity 18 (CAS 76350-03-3)
- Iopromide Impurity 28 (CAS CATO-C4X-183228)
- Iopromide Impurity 30 (CAS CATO-C4X-183230)
- Iopromide Impurity 11 (CAS CATO-C4X-183211)
- Iopromide EP Impurity H (CAS 185459-57-8)
- Iopromide EP Impurity A (CAS 154361-51-0)
- Iopromide impurity 16 (CAS CATO-C4X-183216)
- Iopromide EP Impurity B (CAS 76350-28-2)
Recommended Standards
- 2,3,13,14-Tetrabromo-6,7,9,10,17,18-hexahydrodibenzo[b,h][1,4,7,10,13]penta (CAS 302929-47-1)
- 2,2,7,7-Tetrabromo-9,9-spirobifluorene (CAS 128055-74-3)
- Maraviroc RC2 (CAS 1391048-12-6)
- Tetrabromobisphenol A Bis(2-hydroxyethyl) Ether (CAS 4162-45-2)
- Pirfenidone Impurity 37 (CAS CATO-C4X-222937)
- Crisaborole lmpurity 73 (CAS 2473730-47-9)
- Moxifloxacin impurity 194 (CAS CATO-C4X-1074194)
- Bempedoic Acid Impurity N3 (CAS 764-97-6)
- N-(5-(Benzo[d][1,3]dioxol-5-yl)-1,3,4-oxadiazol-2-yl)cyclopropanecarboxamide (CAS 922018-23-3)
- {[(3,5-Difluorophenyl)methyl]sulfanyl}methanimidamide hydrobromide (CAS 1326812-55-8)
- 1-(2-Bromophenyl)-2-(trifluoromethoxy)ethan-1-amine (CAS 1334147-62-4)
- (5,5-Difluorotetrahydro-2H-pyran-2-yl)methanol (CAS 1823910-57-1)
- 696626-43-4 1-[2-(3,4-Dihydroisoquinolin-2(1H)-yl)-2-oxoethyl]-1H-indole-2,3-dione MFCD05855169 (CAS 696626-43-4)
- Insulin Glargine (CAS 160337-95-1)
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