2-(Chloroacetyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline CAS 111631-72-2
| CAS No. | 111631-72-2 |
| Molecular Formula | C13H16ClNO3 |
| Molecular Weight | 269.72 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 2-(Chloroacetyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline (C13H16ClNO3) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
2-(Chloroacetyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline (CAS 111631-72-2), molecular formula C13H16ClNO3 and molecular weight 269.72 g/mol, is a CATO reference standard with documented purity and traceability.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 2-(Chloroacetyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H16ClNO3 |
| Molecular Weight | 269.72 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Chloroacetyl Standards
- Butyl 4-[(chloroacetyl)amino]benzoate (CAS 106214-24-8)
- Ethyl (2-chloroacetyl)-L-phenylalaninate (CAS 76385-55-2)
- Methyl 4-(2-chloroacetyl)-1-cyclopropyl-2,5-dimethyl-1h-pyrrole-3-carboxylate (CAS 874594-07-7)
- methyl 4-(2-chloroacetyl)-3,4-dihydro-2H-1,4-benzoxazine-2-carboxylate (CAS 949980-36-3)
- 1-(4-(2-Chloroacetyl)piperazin-1-yl)cyclohexane-1-carbonitrile (CAS 879362-89-7)
- 1-[4-(2-Chloroacetyl)-1-piperazinyl]cyclohexanecarbonitrile (CAS 923130-57-8)
- 4-(2-Chloroacetyl)-1,2-phenylene Diacetate (CAS 100945-19-5)
- 3-[(chloroacetyl)(2-methoxyphenyl)amino]propanamide (CAS 929973-88-6)
Recommended Standards
- 2-Chloro-n-(2,3-dihydro-1,4-benzodioxin-2-ylmethyl)-n-methylpropanamide (CAS 1098361-12-6)
- 3-(7-Chloro-2-methyl-2,3-dihydro-1,4-benzoxazepin-4(5H)-yl)propanoic acid (CAS 1119452-95-7)
- 2-Chloro-4-(4-methoxypiperidine-1-carbonyl)phenol (CAS 1096859-74-3)
- 2-Chloro-n-[1-(2,3-dihydro-1,4-benzodioxin-6-yl)ethyl]propanamide (CAS 1154010-13-5)
- 4-Desmethoxy-4-nitro Omeprazole Sulfide (CAS 142885-91-4)
- 1-Azaspiro[5.5]undecane (CAS 180-73-4)
- Ethyl 2-(2,6-Dimethyl-1-piperidyl)acetate (CAS 91370-59-1)
- (E)-N'-(4-methylbenzylidene)-2-(4-(trifluoromethyl)phenoxy)acetohydrazide (CAS 860649-72-5)
- 2-(2-Aminobutan-2-yl)-5-ethyl-6-methylpyrimidin-4(1h)-one hydrochloride (CAS 1354950-93-8)
- 1-(3-Chloropyridin-4-yl)piperazine trihydrochloride (CAS 1707602-64-9)
- 2-[2,6-Dinitro-4-(trifluoromethyl)phenyl]-N-(4-fluorophenyl)hydrazinecarbothioamide (CAS 454453-49-7)
- 1-(4-(Difluoromethyl)phenyl)ethan-1-one (CAS 179990-93-3)
- Naphthofluorescein diacetate (CAS 77084-71-0)
- Semaglutide impurity 26 (CAS CATO-C4X-222626)
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