Afatinib Impurity 39 CAS 1117-71-1

Purity >80%In StockPharmacopoeial Impurity Standards
CAS No.1117-71-1
Molecular FormulaC5H7BrO2
Molecular Weight179.01 g/mol
CategoryPharmacopoeial Impurity Standards / EP Impurities
AvailabilityIn Stock

Chemical Structure

Afatinib Impurity 39 CAS 1117-71-1 chemical structure

Description

CATO supplies Afatinib Impurity 39 (CAS 1117-71-1), a pharmacopoeial impurity reference standard (molecular formula C5H7BrO2, MW 179.01 g/mol) used for the identification and quantification of trace impurities in APIs.

The molecular framework of Afatinib Impurity 39 (C5H7BrO2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, bromine substitution. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.

This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.

CATO manufactures Afatinib Impurity 39 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.

Physical & Chemical Properties

Molecular FormulaC5H7BrO2
Molecular Weight179.01 g/mol
Purity>80%
StorageStore at 2-8°C, keep tightly closed to prevent evaporation
Solubility (reference)Soluble in methanol, acetonitrile, DMSO, water (slightly soluble)
StabilityContains ester bond; hydrolyzes under strong alkaline conditions
Degree of Unsaturation (DBE)2.0
CAS Registry Year (est.)1957
Halogen ContentBr-containing

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