Tamsulosin EP Impurity B HCl CAS 112101-75-4
| CAS No. | 112101-75-4 |
| Molecular Formula | C10H16N2O3S |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Tamsulosin EP Impurity B HCl (CAS 112101-75-4) is a certified pharmaceutical impurity reference standard with the molecular formula C10H16N2O3SHCl and a molecular weight of 280.77 g/mol.
The molecular framework of Tamsulosin EP Impurity B HCl (C10H16N2O3SHCl) is characterized by an amide group, a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H16N2O3S HCl |
| Molecular Weight | 280.77 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Tamsulosin Standards
- Tamsulosin Impurity 68 (CAS 1027854-97-2)
- Tamsulosin EP Impurity F HCl (CAS 1051368-80-9)
- Tamsulosin EP Impurity E (CAS 105764-07-6)
- (R)-Tamsulosin (CAS 106133-20-4)
- Tamsulosin EP Impurity G (CAS 106138-88-9)
- Tamsulosin Hydrochloride (CAS 106463-17-6)
- Tamsulosin EP Impurity G HCl (CAS 106463-19-8)
- Tamsulosin Impurity 59 (CAS 1073231-99-8)
Recommended Standards
- Oseltamivir Impurity 112 (CAS CATO-C4X-1720112)
- Itraconazole Impurity 92 (CAS CATO-C4X-149792)
- Sitafloxacin impurity 58 (CAS CATO-C4X-115558)
- (E)-4-((1H-indol-3-yl)methylene)-3-(chloromethyl)isoxazol-5(4H)-one (CAS 1142199-56-1)
- 4-Fluoro-5-methoxy-1-methyl-1H-pyrazole-3-carboxylic acid (CAS 1774891-89-2)
- 2-Fluoro-6-(3-(trifluoromethyl)phenoxy)benzonitrile (CAS 946387-10-6)
- Betamethasone Impurity N82 (CAS 123013-29-6)
- Beraprost Impurity 8 (CAS CATO-C4X-21848)
- Butyl 4-bromo-2-ethoxybenzamide (CAS 1261895-85-5)
- Semaglutide Impurity 140 (CAS CATO-C4X-2226140)
Why CATO?
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