Tamsulosin EP Impurity G HCl CAS 106463-19-8
| CAS No. | 106463-19-8 |
| Molecular Formula | C20H28N2O5S |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Tamsulosin EP Impurity G HCl (CAS 106463-19-8, C20H28N2O5SHCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Tamsulosin EP Impurity G HCl (C20H28N2O5SHCl) contains a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Tamsulosin EP Impurity G HCl meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C20H28N2O5S HCl |
| Molecular Weight | 444.97 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Tamsulosin Standards
- Tamsulosin Impurity 68 (CAS 1027854-97-2)
- Tamsulosin EP Impurity F HCl (CAS 1051368-80-9)
- Tamsulosin EP Impurity E (CAS 105764-07-6)
- (R)-Tamsulosin (CAS 106133-20-4)
- Tamsulosin EP Impurity G (CAS 106138-88-9)
- Tamsulosin Hydrochloride (CAS 106463-17-6)
- Tamsulosin Impurity 59 (CAS 1073231-99-8)
- Tamsulosin EP Impurity B HCl (CAS 112101-75-4)
Recommended Standards
- Apixaban Impurity 26 (CAS 1643330-62-4)
- Sapropterin Impurity 5 (CAS 17838-80-1)
- Fluconazole EP Impurity G (R-Isomer) (CAS CATO-C4X-101965)
- (R)-4-Bromo-N-(1-hydroxypropan-2-yl)benzenesulfonamide (CAS 202751-85-7)
- tert-butyl morpholine-3-carboxylate hydrochloride (CAS 1269446-54-9)
- (S)-(6,6'-Dimethoxybiphenyl-2,2'-diyl)bis[bis(3,5-di-tert-butylphenyl)phosphine] (CAS 167709-31-1)
- 4-Hydroxy-2-phenyl-8-(trifluoromethyl)quinoline-3-carboxylic acid (CAS 64321-97-7)
- 2-Chloro-N-(3-phenylallyl)acetamide (CAS 31209-29-7)
- 3-Bromo-pyrrolidine-1-carboxylic acid tert-butyl ester 939793-16-5 N-Boc-3-Bromopyrrolidine (CAS 939793-16-5)
- Semaglutide impurity 23 (CAS CATO-C4X-222623)
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