Naltrexone Impurity 19 CAS 112269-62-2
| CAS No. | 112269-62-2 |
| Molecular Formula | C20H23NO5 |
| Molecular Weight | 357.40 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Naltrexone Impurity 19.
As a process- or degradation-related impurity, Naltrexone Impurity 19 (CAS 112269-62-2, C20H23NO5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Naltrexone Impurity 19 (C20H23NO5) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage. The carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Naltrexone Impurity 19 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C20H23NO5 |
| Molecular Weight | 357.40 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Nitrogen Atoms | 1 |
Related Naltrexone Standards
- Naltrexone EP Impurity F (CAS 2397651-97-5)
- Naltrexone Impurity 61 (CAS CATO-C4X-147561)
- Naltrexone EP Impurity G (CAS CATO-C4X-14757)
- Naltrexone impurity 56 (CAS CATO-C4X-147556)
- Naltrexone EP Impurity J (CAS 16617-07-5)
- Naltrexone Impurity 16 (CAS CATO-C4X-147516)
- Naltrexone Impurity N4 (CAS 16676-33-8)
- Naltrexone Impurity 29 (CAS CATO-C4X-147529)
Recommended Standards
- Ketoprofen Impurity 94 (CAS CATO-C4X-147194)
- Ketoprofen Impurity 93 (CAS 2733641-85-3)
- Ketoprofen Impurity 88 (CAS 1984110-22-6)
- Ketoprofen Impurity 60 (CAS 1777830-05-3)
- Cefpodoxime Impurity 62 (CAS CATO-C4X-157962)
- Mosapride Impurity 42 (CAS CATO-C4X-104442)
- Metoclopramide Metoclopramide EP Impurity G Hydrochloride (CAS 171367-22-9（free base）)
- (2-Oxo-2H-[1,2'-bipyridin]-6'-yl)boronic acid (CAS 1310405-02-7)
- 10-(2-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]amino}ethyl)-7-[(E)-2-phenylethenyl]-4-thia-6,10-diazatricyclo[6.3.0.0^{2,6}]undecane-9,11-dione (CAS 321522-14-9)
- (4-Fluoro-2-(1H-imidazol-1-yl)phenyl)methanamine (CAS 869591-89-9)
- 4-(3,4-Dichlorophenyl)piperidin-4-ol (CAS 21928-32-5)
- 2-(1H-Indol-6-yl)ethanol (CAS 321745-14-6)
- H-Homophe-OH (CAS 943-73-7)
- (Asn5)-Delta-Sleep Inducing Peptide (H-2555.0005) (CAS 80064-67-1)
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