Naltrexone Impurity N4 CAS 16676-33-8
| CAS No. | 16676-33-8 |
| Molecular Formula | C21H25NO4 |
| Molecular Weight | 355.43 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 355.43 g/mol gives Naltrexone Impurity N4 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Naltrexone Impurity N4 (CAS 16676-33-8) is a certified pharmaceutical impurity reference standard with the molecular formula C21H25NO4 and a molecular weight of 355.43 g/mol.
Naltrexone Impurity N4 (C21H25NO4) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage. The carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Naltrexone Impurity N4 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C21H25NO4 |
| Molecular Weight | 355.43 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1961 |
| Nitrogen Atoms | 1 |
Related Naltrexone Standards
- Naltrexone EP Impurity J (CAS 16617-07-5)
- Naltrexone Impurity 16 (CAS CATO-C4X-147516)
- Naltrexone EP Impurity I (CAS 96445-14-6)
- Naltrexone Impurity 19 (CAS 112269-62-2)
- Naltrexone EP Impurity F (CAS 2397651-97-5)
- Naltrexone Impurity 61 (CAS CATO-C4X-147561)
- Naltrexone EP Impurity G (CAS CATO-C4X-14757)
- Naltrexone impurity 56 (CAS CATO-C4X-147556)
Recommended Standards
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- L-Tetrahydropalmatine (CAS 483-14-7)
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- Fluconazole Impurity 12 (CAS 188416-33-3)
- Lifitegrast Impurity 89 (CAS CATO-C4X-240989)
- 2-Methoxy-2-(3-pyrrolinomethyl) benzophenone (CAS 898762-85-1)
- 4-((Cyclopropylmethoxy)methyl)-3-fluorobenzaldehyde (CAS 1443338-54-2)
- 3-(((1-(sec-Butyl)-1H-pyrazol-3-yl)amino)methyl)phenol hydrochloride (CAS 1855949-07-3)
- 2-((Benzyloxy)carbonyl)-2-azaspiro[4.4]Nonane-3-carboxylic acid (CAS 2287270-96-4)
- 1-(4-Fluorophenoxy)cyclohexanecarboxylic acid (CAS 1267028-24-9)
- 4-(2-Ethoxyethoxy)-N-(2-isopropoxybenzyl)aniline (CAS 1040687-17-9)
- Semaglutide impurity 237 (CAS CATO-C4X-2226237)
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