Nifuroxazide EP Impurity D CAS 112537-96-9
| CAS No. | 112537-96-9 |
| Molecular Formula | C10H6N4O6 |
| Molecular Weight | 278.18 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Nifuroxazide EP Impurity D.
As a process- or degradation-related impurity, Nifuroxazide EP Impurity D (CAS 112537-96-9, C10H6N4O6) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Nifuroxazide EP Impurity D (C10H6N4O6) contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 10.0, corresponding to approximately 10 ring(s) or double-bond equivalent(s). With a molecular weight of 278.18 g/mol, it falls into the medium-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Nifuroxazide EP Impurity D meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H6N4O6 |
| Molecular Weight | 278.18 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Nitrogen Atoms | 4 |
Related Nifuroxazide Standards
Recommended Standards
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- Sarpogrelate Impurity 18 (CAS 1659311-47-3(free base))
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- Ozanimod Impurity 29 (CAS CATO-C4X-290229)
- 1-Amino-4-bromo-2-(hydroxymethyl)anthracene-9,10-dione (CAS 24094-46-0)
- 4-Bromo-1-ethyl-2-fluorobenzene (CAS 627463-18-7)
- 1-Cyclopropylimidazole (CAS 135207-17-9)
- Trifluoropyruvic acid hydrate (CAS 1081801-99-1)
- 2-(6-Oxo-5-(2-(pentyloxy)benzylidene)-5,6-dihydrothiazolo[3,2-b][1,2,4]triazol-2-yl)phenyl acetate (CAS 617694-63-0)
- 2-Amino-5-(3-methoxyphenyl)-5-[(3,4,5-trimethoxyphenyl)methyl]-4,5-dihydro-1H-imidazol-4-one (CAS 1354924-56-3)
- Myristoyl Pentapeptide-4 (CAS 1392416-25-9)
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