5-(3-Chloro-2-fluorophenyl)nicotinamide CAS 1125445-55-7
| CAS No. | 1125445-55-7 |
| Molecular Formula | C12H8ClFN2O |
| Molecular Weight | 250.66 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), 5-(3-Chloro-2-fluorophenyl)nicotinamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
5-(3-Chloro-2-fluorophenyl)nicotinamide (CAS 1125445-55-7) is a high-purity analytical reference standard with the molecular formula C12H8ClFN2O and a molecular weight of 250.66 g/mol.
Based on its molecular formula C12H8ClFN2O, 5-(3-Chloro-2-fluorophenyl)nicotinamide contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 250.66 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C12H8ClFN2O |
| Molecular Weight | 250.66 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Chloro Standards
- 2-Chloro-N-(3-fluorophenyl)isonicotinamide (CAS 1019323-09-1)
- 2-Chloro-N-(4-fluorophenyl)isonicotinamide (CAS 1019383-51-7)
- 2-Chloro-N-(2-fluorophenyl)isonicotinamide (CAS 1019466-42-2)
- Methyl 2-Chloro-5-sulfamoylnicotinate (CAS 1118787-24-8)
- n-(4-Chloro-2-nitrophenyl)methanesulfonamide (CAS 1249400-38-1)
- n-(2-Chloro-6-nitrophenyl)methanesulfonamide (CAS 1339907-56-0)
- 5-(4-Chloro-2-fluorophenyl)nicotinamide (CAS 1346691-88-0)
- 5-(4-Chloro-3-fluorophenyl)nicotinamide (CAS 1346691-93-7)
Recommended Standards
- 5-Amino-1-(2-chloro-4-fluoro-5-methylphenyl)-1H-pyrazole-4-carbonitrile (CAS 1159678-57-5)
- (S)-3-(1-Azidoethyl)-2-chloro-8-fluoroquinoline (CAS 1065481-28-8)
- Empagliflozin Impurity 285 (CAS CATO-C4X-1065285)
- 5-(5-Chloro-2-fluorophenyl)nicotinamide (CAS 1346692-11-2)
- 3-(4-Chlorophenyl)-N-(pyridin-4-ylmethyl)adamantane-1-carboxamide hydrochloride (CAS 1185157-59-8)
- Methyl 2-(6,8-difluorophenanthren-1-yl)-2-fluoropropanoate (CAS 843614-89-1)
- 2-(4-Amino-2-(difluoromethyl)-5-methylpyridin-3-yl)acetic acid (CAS 1805352-14-0)
- 2-Methyl-5-oxo-4,5-dihydro-1H-pyrrole-3-carbohydrazide (CAS 145888-70-6)
- (s)-3-(1-Amino-2-hydroxyethyl)-2-bromo-6-methoxyphenol (CAS 1213697-81-4)
- Spironolactone Impurity 14 (CAS 53866-20-9)
- 2-Amino-4,5-dibromo-3,6-dichlorobenzoic acid (CAS 861527-29-9)
- N-Boc-2-methylpiperidin-4-amine (CAS 1281674-64-3)
- (S)-3-benzamido-4-methoxy-4-oxobutanoic acid (CAS 82933-21-9)
- Osteogenic Growth Peptide (CAS 132996-61-3)
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