2-(4-Chloro-2-fluoro-3-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane CAS 1126321-06-9
| CAS No. | 1126321-06-9 |
| Molecular Formula | C13H17BClFO3 |
| Molecular Weight | 286.53 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2-(4-Chloro-2-fluoro-3-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane.
CATO supplies 2-(4-Chloro-2-fluoro-3-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 1126321-06-9), a certified reference material (molecular formula C13H17BClFO3, MW 286.53 g/mol) for analytical method development and quality control.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system, 2-(4-Chloro-2-fluoro-3-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 286.53 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H17BClFO3 |
| Molecular Weight | 286.53 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | F/Cl-containing |
Related Chloro Standards
- 2-(4-Chloro-5-fluoro-2-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 1092581-00-4)
- 2-(3-Chloro-5-fluoro-4-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 1422022-15-8)
- 4-Chloro-3-fluoro-2-methoxyphenylboronic acid pinacol ester (CAS 1628524-83-3)
- 2-(6-Chloro-2-fluoro-3-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 1628684-12-7)
- (2-Chloro-4-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol (CAS 2068789-77-3)
- 2-(2-Chloro-5-fluoro-4-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 2445647-03-8)
- 2-(3-Chloro-2-fluoro-4-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 2121512-36-3)
- 2-(3-Chloro-5-fluoro-2-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 2121514-87-0)
Recommended Standards
- 1187163-49-0 5-(4-Bromo-2-fluorophenyl)-2-chloropyridine MFCD13152467 (CAS 1187163-49-0)
- Methylenebis[dimethyl(2-pyridyl)silane] (CAS 243468-48-6)
- 2-Bromo-5-methoxypyridine-4-sulfonyl chloride (CAS 1261467-92-8)
- 4-Amino-6-bromo-2-chloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile (CAS 2177263-53-3)
- 2,6-Dichloro-4-methylcinnamic acid (CAS 1807369-71-6)
- Ethyl 2-((4-(4-fluorophenyl)pyrimidin-2-yl)thio)acetate (CAS 828276-28-4)
- 3-Formamido-3-methylbutanoic acid (CAS 89531-50-0)
- Aztreonam Dimer Impurity N3 (CAS 730928-60-6)
- 6-Bromochroman-3-amine (CAS 757956-65-3)
- 5-Phenyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carbonyl chloride (CAS 696649-33-9)
- (6-Cyclobutyl-4-fluoropyridin-3-yl)boronic acid (CAS 2225176-78-1)
- Etoricoxib Impurity 76 (CAS CATO-C4X-108076)
- (5-Fluoro-2-(isopentyloxy)phenyl)(methyl)sulfane (CAS 1443311-14-5)
- Insulin Degludec Impurity 6 (CAS CATO-C4X-21576)
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