2-(6-Chloro-2-fluoro-3-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane CAS 1628684-12-7
| CAS No. | 1628684-12-7 |
| Molecular Formula | C13H17BClFO3 |
| Molecular Weight | 286.53 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
2-(6-Chloro-2-fluoro-3-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 1628684-12-7), molecular formula C13H17BClFO3 and molecular weight 286.53 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 2-(6-Chloro-2-fluoro-3-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (C13H17BClFO3) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 2-(6-Chloro-2-fluoro-3-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H17BClFO3 |
| Molecular Weight | 286.53 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1993 |
| Halogen Content | F/Cl-containing |
Related Chloro Standards
- 2-(4-Chloro-5-fluoro-2-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 1092581-00-4)
- 2-(4-Chloro-2-fluoro-3-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 1126321-06-9)
- 2-(3-Chloro-5-fluoro-4-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 1422022-15-8)
- 4-Chloro-3-fluoro-2-methoxyphenylboronic acid pinacol ester (CAS 1628524-83-3)
- (2-Chloro-4-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol (CAS 2068789-77-3)
- 2-(2-Chloro-5-fluoro-4-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 2445647-03-8)
- 2-(3-Chloro-2-fluoro-4-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 2121512-36-3)
- 2-(3-Chloro-5-fluoro-2-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 2121514-87-0)
Recommended Standards
- 4-Bromo-3-methoxypyridine-2-sulfonyl chloride (CAS 1804848-48-3)
- 4-Bromo-5-methoxypyridine-2-sulfonyl chloride (CAS 1807214-64-7)
- 6-Bromo-2-methoxypyridine-3-sulfonyl chloride (CAS 1261866-85-6)
- 2-Bromo-6-methoxypyridine-4-sulfonyl chloride (CAS 1261625-45-9)
- 4-[(1R)-1-amino-2-methoxyethyl]-benzonitrile (CAS 1269968-25-3)
- 2-Cyclopropylpropan-1-amine 4-methylbenzenesulfonate (CAS 172947-14-7)
- 6,8-Dichloro-1h,2h,3h,4h,5h-pyrido[4,3-b]indole hydrochloride (CAS 1197477-27-2)
- 4-(Allyloxy)-2,3-dibromo-5-ethoxybenzaldehyde (CAS 832673-80-0)
- 1,7-Dimethyl-1H-benzo[d]imidazol-2(3H)-one (CAS 24133-89-9)
- (5Z)-5-Dodecen-1-ol (CAS 40642-38-4)
- Cabazitaxel Impurity 8 (CAS CATO-C4X-11158)
- 1-(5-Ethoxy-2-fluorophenyl)ethanol (CAS 1554353-36-4)
- 2-Oxa-5-azabicyclo[2.2.1]Heptane-4-carboxylic acid (CAS 1860808-48-5)
- Acetyl Tetrapeptide-5 (CAS 820959-17-9)
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