Vonoprazan Impurity 195 CAS 1126403-28-8
| CAS No. | 1126403-28-8 |
| Molecular Formula | C20H33N3O4 |
| Molecular Weight | 379.49 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Vonoprazan Impurity 195 (CAS 1126403-28-8) is a certified pharmaceutical impurity reference standard with the molecular formula C20H33N3O4 and a molecular weight of 379.49 g/mol.
Based on its molecular formula C20H33N3O4, Vonoprazan Impurity 195 contains a steroid core, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 379.49 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C20H33N3O4 |
| Molecular Weight | 379.49 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Nitrogen Atoms | 3 |
Related Vonoprazan Standards
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- 2-(Hydroxymethyl)furo[3,2-b]pyridin-6-ol (CAS 1186310-89-3)
- 2-(Difluoromethyl)-3,5-dimethoxypyridin-4-amine (CAS 1805159-03-8)
- (D-Trp32)-Neuropeptide Y (porcine) trifluoroacetate salt (CAS 153549-78-1)
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