4-Chloro-2-fluoro-5-methylbenzonitrile CAS 1126424-34-7
| CAS No. | 1126424-34-7 |
| Molecular Formula | C8H5ClFN |
| Molecular Weight | 169.58 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4-Chloro-2-fluoro-5-methylbenzonitrile.
CATO supplies 4-Chloro-2-fluoro-5-methylbenzonitrile (CAS 1126424-34-7), a certified reference material (molecular formula C8H5ClFN, MW 169.58 g/mol) for analytical method development and quality control.
4-Chloro-2-fluoro-5-methylbenzonitrile (C8H5ClFN) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 4-Chloro-2-fluoro-5-methylbenzonitrile meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H5ClFN |
| Molecular Weight | 169.58 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Chloro Standards
- 7-Chloro-4-fluoro-1H-indole (CAS 1000341-60-5)
- 4-Chloro-7-fluoro-1h-indole (CAS 1000341-78-5)
- 4-Chloro-2-fluoro-3-methylbenzonitrile (CAS 1207875-88-4)
- 6-Chloro-5-fluoro-1H-indole (CAS 122509-72-2)
- 5-Chloro-7-fluoro-1H-indole (CAS 1227499-38-8)
- 2-Chloro-2-(2-fluorophenyl)acetonitrile (CAS 1247740-42-6)
- 5-Chloro-2-fluoro-1H-indole (CAS 1354220-70-4)
- 5-Chloro-3-fluoro-2-methylbenzonitrile (CAS 1365969-38-5)
Recommended Standards
- 2-(4-chlorophenyl)-2-fluoroacetonitrile (CAS 106468-05-7)
- 6-Chloro-2-Benzoxazolinone (CAS 19932-84-4)
- Chlorzoxazone (CAS 95-25-0)
- 4-Cyano-3-fluorobenzyl chloride (CAS 1260814-48-9)
- Cyclohexanamine (2S,3S,4S,5R,6S)-6-((5-bromo-1H-indol-3-yl)oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylate (CAS 199326-16-4)
- 2-(Difluoromethoxy)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (CAS 1425334-94-6)
- 3-(Cyclopropylmethyl)-5-(methylthio)phenol (CAS 1243474-68-1)
- 2-bromo-5-isopropyl-1H-imidazole (CAS 1785314-93-3)
- ((5-Acetamido-2-methoxyphenyl)azanediyl)bis(ethane-2,1-diyl) diacetate (CAS 23128-51-0)
- 2,4-Dimethyl-7-nitro-1H-benzo[d]imidazole (CAS 23291-70-5)
- 2,3,6-Trifluoro-5-nitropyridin-4-amine (CAS 405230-88-8)
- Ambroxol Maillard Lactose Impurity 6(Ambroxol Impurity 75) (CAS CATO-C4X-108575)
- N,N'-Dimorpholinomethane (CAS 5625-90-1)
- D-[Ser]8-Liraglutide (CAS CATO-C4X-199238)
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