Prilocaine Impurity 25 CAS 112843-97-7
| CAS No. | 112843-97-7 |
| Molecular Formula | C12H13Cl2NO2 |
| Molecular Weight | 274.14 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Prilocaine Impurity 25 (CAS 112843-97-7) is a certified pharmaceutical impurity reference standard with the molecular formula C12H13Cl2NO2 and a molecular weight of 274.14 g/mol.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Prilocaine Impurity 25 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 274.14 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H13Cl2NO2 |
| Molecular Weight | 274.14 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Prilocaine Standards
- Prilocaine Impurity 23 (CAS 95827-14-8)
- Prilocaine impurity 53 (CAS CATO-C4X-193453)
- Prilocaine Impurity 63 (CAS CATO-C4X-193463)
- Prilocaine Impurity 64 (CAS CATO-C4X-193464)
- Prilocaine Impurity 11 (CAS CATO-C4X-193411)
- Prilocaine impurity 36 (CAS CATO-C4X-193436)
- Prilocaine Impurity 35 (CAS CATO-C4X-193435)
- Prilocaine impurity 39 (CAS CATO-C4X-193439)
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