Prilocaine Impurity 23 CAS 95827-14-8
| CAS No. | 95827-14-8 |
| Molecular Formula | C10H10Cl3NO |
| Molecular Weight | 266.55 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Prilocaine Impurity 23 (C10H10Cl3NO) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
CATO supplies Prilocaine Impurity 23 (CAS 95827-14-8), a pharmacopoeial impurity reference standard (molecular formula C10H10Cl3NO, MW 266.55 g/mol) used for the identification and quantification of trace impurities in APIs.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H10Cl3NO |
| Molecular Weight | 266.55 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1984 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Prilocaine Standards
- Prilocaine impurity 53 (CAS CATO-C4X-193453)
- Prilocaine Impurity 63 (CAS CATO-C4X-193463)
- Prilocaine Impurity 25 (CAS 112843-97-7)
- Prilocaine Impurity 64 (CAS CATO-C4X-193464)
- Prilocaine Impurity 11 (CAS CATO-C4X-193411)
- Prilocaine impurity 36 (CAS CATO-C4X-193436)
- Prilocaine Impurity 35 (CAS CATO-C4X-193435)
- Prilocaine impurity 39 (CAS CATO-C4X-193439)
Recommended Standards
- 2-Chloro-N-[2-(2,4-dichlorophenyl)ethyl]acetamide (CAS 34162-22-6)
- 6-bromo-3-chloro-5,6,7,8-tetrahydroisoquinolin-5-one (CAS 1105662-41-6)
- 2-Chloro-n-[1-(3,4-dichlorophenyl)ethyl]acetamide (CAS 90793-96-7)
- 2-(4-Chloro-3,5-dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 1111096-20-8)
- Cidofovir Impurity 2 HCl (CAS 3038741-00-0)
- Baloxavir Marboxil Impurity 209 HCl (CAS 2417354-05-1 (free base))
- Ibutilide Impurity 8 (CAS CATO-C4X-21108)
- 5-(4-Fluorophenyl)-3,3-dimethylpentanoic acid (CAS 1341062-14-3)
- 5,6-Dimethylpyrrolo[2,1-f][1,2,4]triazin-4-ol (CAS 721943-81-3)
- 2-(4-Ethyl-2,3-dioxopiperazin-1-yl)-N-(3-methoxyphenyl)acetamide (CAS 868680-50-6)
- 6-chlorospiro[chromane-2,4'-piperidine] hydrochloride (CAS 909035-22-9)
- 7-iodo-2-methyl-2H-indazole (CAS 1216694-71-1)
- 2-CHloro-1,1,1,3-tetrafluorobut-2-ene (CAS 885276-06-2)
- TRAF6 Control Peptide trifluoroacetate salt (CAS 852690-80-3)
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