莫沙必利杂质26 CAS 112886-58-5
| CAS No. | 112886-58-5 |
| Molecular Formula | C21H25ClFN3O3 |
| Molecular Weight | 421.89 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), 莫沙必利杂质26 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, 莫沙必利杂质26 (CAS 112886-58-5, C21H25ClFN3O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
莫沙必利杂质26 (C21H25ClFN3O3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C21H25ClFN3O3 |
| Molecular Weight | 421.89 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Recommended Standards
- 1,2-Dibromo-1,2,3,3,3-pentafluoro-1-(2,2,3,3-tetrafluoropropoxy)propane (CAS 396716-51-1)
- Mosapride (CAS 112885-41-3)
- 1-(3-(1H-imidazol-1-yl)propyl)-4-benzoyl-5-(4-chlorophenyl)-3-hydroxy-1,5-dihydro-2H-pyrrol-2-one (CAS 381717-91-5)
- Mosapride Impurity 36 (CAS 112886-56-3)
- Rasagiline Impurity 6 HCl (CAS 152605-34-0)
- Venetoclax Impurity 54 (CAS CATO-C4X-249554)
- Selumetinib Impurity 20 (CAS CATO-C4X-305320)
- 1-(4-Methylpiperidin-1-yl)propan-2-amine (CAS 24633-50-9)
- (4-(6-Chloropyridin-2-yl)piperazin-1-yl)(4-fluorophenyl)methanone (CAS 339107-32-3)
- 1-(4-Bromo-1-methyl-2-(methylthio)-1H-imidazol-5-yl)-2-(5-methylpyrazin-2-yl)ethanone (CAS 108905-64-2)
- 1-(6-(4-Methylpiperidin-1-yl)pyrimidin-4-yl)-3-(thiophen-2-ylmethyl)urea (CAS 1396858-80-2)
- 1-Methyl-3-(4-phenoxyphenyl)-2-thioxoimidazolidin-4-one (CAS 854137-28-3)
- 4-Amino-2-chloro-N-(isobutyl)benzamide (CAS 926218-95-3)
- Semaglutide impurity 80 (CAS CATO-C4X-222680)
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