Venetoclax Impurity 54 CAS CATO-C4X-249554
| CAS No. | CATO-C4X-249554 |
| Molecular Formula | C39H40ClN7O6S |
| Molecular Weight | 770.30 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Venetoclax Impurity 54 (CAS CATO-C4X-249554, C39H40ClN7O6S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Venetoclax Impurity 54 (C39H40ClN7O6S) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C39H40ClN7O6S |
| Molecular Weight | 770.30 g/mol |
| Purity | ≥95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 23.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 7 |
| Sulfur Atoms | 1 |
Related Venetoclax Standards
- Venetoclax Impurity 105 (CAS CATO-C4X-2495105)
- Venetoclax Impurity 115 (CAS CATO-C4X-2495115)
- Venetoclax Impurity 91 (CAS CATO-C4X-249591)
- Venetoclax Impurity 112 (CAS CATO-C4X-2495112)
- Venetoclax Impurity 134 (CAS CATO-C4X-2495134)
- Venetoclax Impurity 21 (CAS CATO-C4X-249521)
- Venetoclax Impurity 8 (CAS 2573767-91-4)
- Venetoclax Impurity 100 (CAS CATO-C4X-2495100)
Recommended Standards
- Glyceryl-d5 Tripentadecanoate (CAS 1219804-57-5)
- (((4R,5R)-2,2-Dimethyl-1,3-dioxolane-4,5-diyl)bis(methylene))bis(bis(4-(trifluoromethyl)phenyl)phosphane) (CAS 1435707-78-0)
- N-(5-Oxo-1-(2,4,6-trichlorophenyl)-4,5-dihydro-1H-pyrazol-3-yl)-3-(2-(3-pentadecylphenoxy)butanamido)benzamide (CAS 65339-11-9)
- (((4S,5S)-2,2-Dimethyl-1,3-dioxolane-4,5-diyl)bis(methylene))bis(bis(4-(trifluoromethyl)phenyl)phosphane) (CAS 184095-64-5)
- Brexpiprazole Impurity 76 HCl (CAS CATO-C4X-113176)
- CAS CATO-C4X-34216 (CAS CATO-C4X-34216)
- Upadacitinib Impurity 159 (CAS CATO-C4X-2405159)
- (1,3-Phenylenebis(methylene))diphosphonic acid (CAS 144052-40-4)
- Pip-alkyne-Ph-COOCH3 (CAS 2308496-47-9)
- 1-(3-methylisoxazol-5-yl)ethan-1-one (CAS 55086-61-8)
- (4-Amino-6-(3-methylpiperidin-1-yl)-5-nitropyrimidin-2-yl)glycine (CAS 714285-83-3)
- (2s)-2-Amino-2-(2-(pyrrolidin-2-yl)phenyl)ethan-1-ol (CAS 1213680-01-3)
- 2-((Benzyloxy)carbonyl)-5-(tert-butoxycarbonyl)hexahydropyrrolo[3,4-c]pyrrole-3a(1H)-carboxylic acid (CAS 1823494-74-1)
- Semaglutide impurity 63 (CAS CATO-C4X-222663)
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