2-Chloro-6-fluoroquinazoline CAS 113082-27-2
| CAS No. | 113082-27-2 |
| Molecular Formula | C8H4ClFN2 |
| Molecular Weight | 182.58 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2-Chloro-6-fluoroquinazoline.
2-Chloro-6-fluoroquinazoline (CAS 113082-27-2), molecular formula C8H4ClFN2 and molecular weight 182.58 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 2-Chloro-6-fluoroquinazoline (C8H4ClFN2) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 2-Chloro-6-fluoroquinazoline meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H4ClFN2 |
| Molecular Weight | 182.58 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Chloro Standards
- 2-chloro-3-fluoro-4-nitro-pyridine (CAS 109613-90-3)
- 6-Chloro-2-fluoroquinoxaline (CAS 112080-05-4)
- 6-chloro-5-fluoro-pyrimidine-4-carboxylic acid (CAS 1256785-64-4)
- 2-Chloro-7-fluoro-1,5-naphthyridine (CAS 1378470-92-8)
- 2-Chloro-8-fluoroquinazoline (CAS 1388055-06-8)
- 8-Chloro-3-fluoro-1,7-naphthyridine (CAS 1393532-49-4)
- 1-(2-Chloro-4-fluorophenyl)prop-2-yn-1-one (CAS 1477879-38-1)
- 2-Chloro-7-fluoro-1,6-naphthyridine (CAS 1574395-53-1)
Recommended Standards
- Tofacitinib impurity 195 (CAS CATO-C4X-1079195)
- 1H-Purine-6-carbonyl chloride (CAS 70265-75-7)
- 2-Chloropteridin-4(3H)-one (CAS 1710854-45-7)
- 4-Chloropteridin-7(8H)-one (CAS 1707585-86-1)
- 3-(Benzo[d][1,3]dioxol-5-yl)isothiazole-4-carboxylic acid (CAS 67049-03-0)
- 4-Amino-3-methyl-5-oxo-4,5-dihydro-1H-1,2,4-triazole-1-carboxamide (CAS 138220-11-8)
- (S)-Citalopram (CAS 128196-01-0)
- Ribociclib Impurity 6 (CAS 2470164-21-5)
- 5-bromo-1,7-naphthyridin-8-amine (CAS 67967-17-3)
- Cefadroxil EP Impurity G（Cefradine EP Impurity F/Cefalexin EP Impurity D） (CAS 34876-35-2)
- Rifampicin EP Impurity B (CAS 125833-03-6)
- 4-(3,4-Diethoxy-phenyl)-4-oxo-butyric acid (CAS 63213-42-3)
- 3-Bromo-1-phenyl-1H-indole-2-carboxylic acid (CAS 1248549-40-7)
- 69558-55-0 O3Y80ZF13F Thymopentin Thymopentin [USAN:INN:BAN] L-Tyrosine, N-(N-(N-(N2-L-arginyl-L-lysyl)-L-alpha-aspartyl)-L-valyl)- L-Tyrosine, N-(N-(N-(N(sup 2)-L-arginyl-L-lysyl)-L-alpha-aspartyl)-L-valyl)- Thymopentine [French] Thymopentinum [Latin] Timopentina [Spanish] Thymopoietin 32-36 TP-5 Thymopoietin pentapeptide ORF-15244 Thymopentine Thymopentinum Timopentina ORF 15244 UNII-O3Y80ZF13F (CAS 69558-55-0)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com