Tofacitinib impurity 195 CAS CATO-C4X-1079195
| CAS No. | CATO-C4X-1079195 |
| Molecular Formula | C6H3ClN4O |
| Molecular Weight | 182.57 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Tofacitinib impurity 195 is closely related to an amide group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Tofacitinib impurity 195 (CAS CATO-C4X-1079195) is a certified pharmaceutical impurity reference standard with the molecular formula C6H3ClN4O and a molecular weight of 182.57 g/mol.
The molecular framework of Tofacitinib impurity 195 (C6H3ClN4O) is characterized by an amide group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6H3ClN4O |
| Molecular Weight | 182.57 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
Related Tofacitinib Standards
- Tofacitinib Impurity 149 (CAS 861612-04-6)
- Tofacitinib Impurity 193 (CAS CATO-C4X-1079193)
- Tofacitinib Impurity 197 (CAS CATO-C4X-1079197)
- Tofacitinib Impurity 183 (CAS 115093-90-8)
- Tofacitinib Impurity 60 (CAS 90213-66-4)
- Tofacitinib Impurity 124 (CAS 14446-71-0)
- Tofacitinib Impurity 127 (CAS 1204176-45-3)
- Tofacitinib Impurity 246 (CAS CATO-C4X-1079246)
Recommended Standards
- 1H-Purine-6-carbonyl chloride (CAS 70265-75-7)
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- 6-Chloro-2-fluoroquinoxaline (CAS 112080-05-4)
- Ketoprofen EP Impurity H (CAS 5689-33-8)
- Troxerutin Impurity 11 (CAS CATO-C4X-280011)
- Molnupiravir Impurity N7 (CAS 2346620-53-7)
- 2-(((2-Hydroxypropyl)amino)methyl)-5-methoxyphenol (CAS 1248398-28-8)
- 2-(4-Fluorophenyl)ethanamine Hydrochloride (CAS 459-19-8)
- Bedaquiline Fumarate (Mixture of Enantiomers) (CAS 2747938-36-7)
- (E)-3-[4-(dimethylamino)phenyl]-2-[(4-methylphenyl)sulfonyl]-2-propenenitrile 16092-97-0 KS-0000293W (CAS 16092-97-0)
- N8-Methylquinoline-5,8-diamine (CAS 1154579-88-0)
- Thiazolidine 1,1-dioxide hydrochloride (CAS 148296-23-5)
- D-Tyr10-Tirzepatide (CAS CATO-CPTD788922)
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