Pretomanid Impurity 4 CAS 1131004-99-3
| CAS No. | 1131004-99-3 |
| Molecular Formula | C14H12F3N3O5 |
| Molecular Weight | 359.26 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Pretomanid Impurity 4 (CAS 1131004-99-3, C14H12F3N3O5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Pretomanid Impurity 4 (C14H12F3N3O5) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H12F3N3O5 |
| Molecular Weight | 359.26 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | ＞95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Pretomanid Standards
- Pretomanid (CAS 187235-37-6)
- Pretomanid Impurity 15 (CAS 1353753-57-7)
- Pretomanid Impurity 16 (CAS CATO-C4X-260616)
- Pretomanid Impurity 2 (CAS 1105708-11-9)
- Pretomanid Impurity 8 (CAS CATO-C4X-26068)
- Pretomanid-4d (CAS 1346617-34-2)
- Pretomanid Impurity 18 (CAS CATO-C4X-260618)
- Pretomanid Impurity 3 (CAS 2755727-09-2)
Recommended Standards
- tert-Butyl (1-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)cyclopropyl)carbamate (CAS 1004294-78-3)
- tert-Butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydroisoquinoline-2(1H)-carboxylate (CAS 1035235-26-7)
- 【停用，请询C4X-260615】Pretomanid Impurity 11 (CAS CATO-C4X-260611)
- tert-Butyl 2-(2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)phenyl)pyrrolidine-1-carboxylate (CAS 1224945-51-0)
- Capivasertib Impurity 32 (CAS CATO-C4X-331232)
- Amlodipine Impurity 136 (CAS CATO-C4X-1095136)
- Dosulepin EP Impurity E (CAS 25627-38-7)
- 0552AD 1185304-66-8 C13H16Cl2N2 [4-(2-Pyridin-3-ylethyl)phenyl]amine dihydrochloride (CAS 1185304-66-8)
- 4-Methyl-8-quinoxalinesulfonyl Chloride (CAS 13982-84-8)
- Butyl[(4-tert-Butylphenyl)methyl]amine hydrochloride (CAS 1240568-28-8)
- 5-(3-methylphenyl)-1,3-thiazol-2-amine (CAS 1178168-92-7)
- 3-([1,1'-Biphenyl]-4-yl(phenyl)phosphino)benzoic acid (CAS 62350-80-5)
- N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)hydrazinecarbothioamide (CAS 96447-49-3)
- Endo-38a-Pro-Exenatide trifluoroacetate salt (CAS 1678416-95-9)
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