Pretomanid Impurity 26 CAS 1131005-00-9
| CAS No. | 1131005-00-9 |
| Molecular Formula | C14H13F3N2O3 |
| Molecular Weight | 314.26 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution, Pretomanid Impurity 26 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 314.26 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Pretomanid Impurity 26 (CAS 1131005-00-9) is a certified pharmaceutical impurity reference standard with the molecular formula C14H13F3N2O3 and a molecular weight of 314.26 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Pretomanid Impurity 26 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C14H13F3N2O3 |
| Molecular Weight | 314.26 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Pretomanid Standards
- Pretomanid Impurity 9 (CAS CATO-C4X-26069)
- Pretomanid Impurity 22 (CAS CATO-C4X-260622)
- Pretomanid Impurity 25 (CAS CATO-C4X-260625)
- Pretomanid Impurity 18 (CAS CATO-C4X-260618)
- Pretomanid Impurity 3 (CAS 2755727-09-2)
- Pretomanid (CAS 187235-37-6)
- Pretomanid Impurity 15 (CAS 1353753-57-7)
- Pretomanid Impurity 16 (CAS CATO-C4X-260616)
Recommended Standards
- Ensitrelvir Impurity 8 (CAS CATO-C4X-25198)
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