Canagliflozin Impurity 112 CAS 1132832-76-8
| CAS No. | 1132832-76-8 |
| Molecular Formula | C36H57FO6SSi4 |
| Molecular Weight | 749.24 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Canagliflozin Impurity 112 (CAS 1132832-76-8, C36H57FO6SSi4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Canagliflozin Impurity 112 (C36H57FO6SSi4) contains a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, a polycyclic aromatic system. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C36H57FO6SSi4 |
| Molecular Weight | 749.24 g/mol |
| Purity | ≥95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | F-containing |
| Sulfur Atoms | 1 |
Related Canagliflozin Standards
- Canagliflozin Impurity 116 (CAS CATO-C4X-1123116)
- Canagliflozin Impurity 102 (CAS CATO-C4X-1123102)
- Canagliflozin Impurity 65 (CAS CATO-C4X-112365)
- Canagliflozin Impurity 94 (CAS CATO-C4X-112394)
- Canagliflozin Impurity 108 (CAS 1908474-06-5)
- Canagliflozin Impurity 39 (CAS 1222075-02-6)
- Canagliflozin Impurity 107 (CAS CATO-C4X-1123107)
- Canagliflozin Impurity 114 (CAS CATO-C4X-1123114)
Recommended Standards
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- (S)-3,3'-Bis(anthracenyl-9-yl)-1,1'-binapthyl-2,2'-diyl hydrogenphosphate 361342-52-1 C48H29O4P (CAS 361342-52-1)
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- Tegoprazan Impurity 17 (CAS 942195-86-0)
- N-(4-Methylpyrimidin-2-yl)formimidamide (CAS 193413-22-8)
- Palmitoyl Tripeptide-1 TFA salt (CAS 2803375-47-3)
- Indapamide Impurity 9 (CAS 1219174-77-2)
- 4-((3-((3-Chlorophenyl)carbamoyl)phenyl)amino)-4-oxobutanoic acid (CAS 307340-35-8)
- N-(3,5-dichlorophenyl)-2-(1-methyl-1H-pyrrol-2-yl)-2-oxoacetamide (CAS 477871-97-9)
- Tris(1-hydroxy-2,2,6,6-tetramethylpiperidin-4-yl) phosphite (CAS 2122-49-8)
- Eledoisin Related Peptide (CAS 2990-43-4)
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