Avibactam Impurity 133 CAS 1133931-73-3

Purity ≥95%In StockPharmacopoeial Impurity Standards
CAS No.1133931-73-3
Molecular FormulaC25H31ClN2O5
Molecular Weight474.98 g/mol
CategoryPharmacopoeial Impurity Standards / EP Impurities
AvailabilityIn Stock

Chemical Structure

Avibactam Impurity 133 CAS 1133931-73-3 chemical structure

Description

Compared with other compounds in its class, the molecular weight of 474.98 g/mol gives Avibactam Impurity 133 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.

Avibactam Impurity 133 (CAS 1133931-73-3) is a certified pharmaceutical impurity reference standard with the molecular formula C25H31ClN2O5 and a molecular weight of 474.98 g/mol.

The molecular framework of Avibactam Impurity 133 (C25H31ClN2O5) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).

Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.

As a certified reference material (CRM), Avibactam Impurity 133 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

Molecular FormulaC25H31ClN2O5
Molecular Weight474.98 g/mol
AppearancePale yellow to yellow crystalline powder. (slight halide-like odor)
Purity≥95%
StorageStore in a cool place (≤25°C), protect from light, keep sealed and dry
Solubility (reference)Soluble in DMSO, DMF, methanol
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions
Degree of Unsaturation (DBE)11.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)1989
Halogen ContentCl-containing
Nitrogen Atoms2

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