2-Chloro-6-ethynyl-5-fluoronicotinonitrile CAS 1134614-73-5
| CAS No. | 1134614-73-5 |
| Molecular Formula | C8H2ClFN2 |
| Molecular Weight | 180.57 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), 2-Chloro-6-ethynyl-5-fluoronicotinonitrile meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
CATO supplies 2-Chloro-6-ethynyl-5-fluoronicotinonitrile (CAS 1134614-73-5), a certified reference material (molecular formula C8H2ClFN2, MW 180.57 g/mol) for analytical method development and quality control.
2-Chloro-6-ethynyl-5-fluoronicotinonitrile (C8H2ClFN2) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C8H2ClFN2 |
| Molecular Weight | 180.57 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Chloro Standards
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Recommended Standards
- 4-Chlorobenzotrifluoride (CAS 98-56-6)
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- 2-Chlorobenzotrifluoride (CAS 88-16-4)
- Tert-butyl 4-cyano-4-(cyclopropylmethyl)piperidine-1-carboxylate (CAS 895132-31-7)
- dibutyl (2-oxo-2-phenylethyl)phosphonate (CAS 1034-94-2)
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- 2-Bromo-1-(3-((trifluoromethyl)thio)phenyl)ethan-1-one (CAS 56773-34-3)
- Ethyl 2-hydroxy-6-phenylnicotinate (CAS 58787-26-1)
- tert-Butyl hexa-1,5-dien-3-ylcarbamate (CAS 175350-70-6)
- 3,5-Diisopropylpyridazin-4-amine (CAS 2397623-91-3)
- 2-(methylamino)-3-oxo-3-phenylpropanal (CAS 569659-46-7)
- (2E)-3-(8-methoxy-2,3-dihydro-1,4-benzodioxin-6-yl)acrylic acid (CAS 852389-16-3)
- Calcineurin Autoinhibitory Peptide (CAS 148067-21-4)
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