4-Chloro-1-(difluoromethyl)-2-fluorobenzene CAS 1214337-46-8
| CAS No. | 1214337-46-8 |
| Molecular Formula | C7H4ClF3 |
| Molecular Weight | 180.55 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO supplies 4-Chloro-1-(difluoromethyl)-2-fluorobenzene (CAS 1214337-46-8), a certified reference material (molecular formula C7H4ClF3, MW 180.55 g/mol) for analytical method development and quality control.
4-Chloro-1-(difluoromethyl)-2-fluorobenzene (C7H4ClF3) contains fluorine/chlorine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), 4-Chloro-1-(difluoromethyl)-2-fluorobenzene meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H4ClF3 |
| Molecular Weight | 180.55 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F/Cl-containing |
Related Chloro Standards
- 1-Chloro-3-(difluoromethyl)-5-fluorobenzene (CAS 1214333-10-4)
- 1-Chloro-3-(difluoromethyl)-2-fluorobenzene (CAS 1214333-71-7)
- 1-Chloro-4-(difluoromethyl)-2-fluoro-benzene (CAS 1214333-76-2)
- 1-Chloro-2-(difluoromethyl)-4-fluorobenzene (CAS 1214347-68-8)
- 2-Chloro-4-(difluoromethyl)-1-fluorobenzene (CAS 1214372-57-2)
- 2-Chloro-1-(difluoromethyl)-3-fluorobenzene (CAS 1214386-88-5)
- 4-Chloro-2-(difluoromethyl)-1-fluorobenzene (CAS 1228898-70-1)
- 1-Chloro-2-(difluoromethyl)-3-fluorobenzene (CAS 63878-72-8)
Recommended Standards
- 1-(Chloromethyl)-2,3,5-trifluorobenzene (CAS 1214378-48-9)
- 2,3,6-Trifluorobenzyl Chloride (CAS 114152-20-4)
- 5-Chloro-6-(difluoromethyl)pyrimidin-4-ol (CAS 425394-28-1)
- 5-Chloro-2,4-difluoro-6-methoxypyrimidine (CAS 27265-89-0)
- 6-Aminoquinolin-8-ol (CAS 68748-35-6)
- N-(tert-butyl)-3-methyl-5-vinylpyridin-2-amine (CAS 1355206-86-8)
- (4-Chloro-2-(cyclopentyloxy)pyrimidin-5-yl)boronic acid (CAS 2225172-44-9)
- 4-(2,6-Dimethylmorpholin-4-yl)-3-nitrobenzoic acid (CAS 942474-64-8)
- Roflumilast Impurity 11 (CAS 159783-78-5)
- Telmisartan Impurity 92 (CAS CATO-C4X-135992)
- 6-Amino-3-bromoimidazo[1,2-a]pyridine (CAS 1099621-14-3)
- 1-(2-Methoxybenzyl)urea hydrochloride (CAS 1221723-18-7)
- [4-(2-{4-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl}ethoxy)phenyl]methanol (CAS 338409-36-2)
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