2-(Naphthalen-2-yloxy)-1-(piperazin-1-yl)ethan-1-one 2,2,2-trifluoroacetate CAS 1135289-91-6
| CAS No. | 1135289-91-6 |
| Molecular Formula | C16H18N2O2 |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
2-(Naphthalen-2-yloxy)-1-(piperazin-1-yl)ethan-1-one 2,2,2-trifluoroacetate (CAS 1135289-91-6), molecular formula C16H18N2O2C2HF3O2 and molecular weight 384.35 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 2-(Naphthalen-2-yloxy)-1-(piperazin-1-yl)ethan-1-one 2,2,2-trifluoroacetate (C16H18N2O2C2HF3O2) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a certified reference material (CRM), 2-(Naphthalen-2-yloxy)-1-(piperazin-1-yl)ethan-1-one 2,2,2-trifluoroacetate meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H18N2O2 C2HF3O2 |
| Molecular Weight | 384.35 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Naphthalen Standards
- 2-(Naphthalen-2-yl)isonicotinic acid (CAS 100004-92-0)
- 2-(Naphthalen-1-yl)isonicotinic acid (CAS 100004-93-1)
- 1-Methyl-2-(naphthalen-1-yl)-1H-imidazole (CAS 1001755-52-7)
- 4,4'-Bis(10-(naphthalen-1-yl)anthracen-9-yl)-1,1'-biphenyl (CAS 1002328-32-6)
- 4-(Naphthalen-1-yl)piperidin-4-ol (CAS 100240-14-0)
- 4-(naphthalen-1-yl)-1,2,3,6-tetrahydropyridine hydrochloride (CAS 100240-18-4)
- Sodium 2-(naphthalen-2-yloxy)acetate (CAS 10042-71-4)
- 1-(Naphthalen-1-yl)ethan-1-one oxime (CAS 100485-51-6)
Recommended Standards
- 1,5-Dichloro-2-(propan-2-yloxy)-3-propoxybenzene (CAS 1881288-43-2)
- 4-Bromo-1-isopropylisoquinoline (CAS 1821161-32-3)
- Methyl 6-amino-4-(2-chlorophenyl)-5-cyano-2-(2-methoxy-2-oxoethyl)-4H-pyran-3-carboxylate (CAS 878656-46-3)
- 2-((Ethylamino)methyl)benzonitrile (CAS 1016510-64-7)
- 7-Fluoro-1-methyl-1,2,3,4-tetrahydroquinoxaline (CAS 1354953-50-6)
- 2,5-Difluoro-1,4-benzenedicarbonitrile (CAS 1897-49-0)
- Chlorphenamine Impurity 61Maleic Acid (CAS 19428-44-5（free base）)
- N-(3,4-dimethoxybenzyl)-6,7-dimethoxyquinazolin-4-amine (CAS 229476-54-4)
- Terbutaline impurity 110 (CAS CATO-C4X-1183110)
- Semaglutide impurity 97 (CAS CATO-C4X-222697)
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