Trimetazidine EP Impurity F（Dihydrochloride） CAS 113698-83-2
| CAS No. | 113698-83-2 |
| Molecular Formula | C14H22N2O3 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 302.80 g/mol gives Trimetazidine EP Impurity F（Dihydrochloride） distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Trimetazidine EP Impurity F（Dihydrochloride） (CAS 113698-83-2, C14H22N2O3HCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Trimetazidine EP Impurity F（Dihydrochloride） (C14H22N2O3HCl) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H22N2O3 2*HCl |
| Molecular Weight | 302.80 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Trimetazidine Standards
- Trimetazidine EP Impurity A DiHCl (CAS 107049-57-0)
- Trimetazidine EP Impurity G (CAS 110-85-0)
- Trimetazidine Impurity 5 (CAS 1133-49-9)
- Trimetazidine-D8 Dihydrochloride (CAS 1219795-37-5)
- Trimetazidine-d8 Dihydrochloride (CAS 1219908-67-4)
- Trimetazidine EP Impurity B (CAS 1257-19-8)
- Trimetazidine Dihydrochloride (CAS 13171-25-0)
- Trimetazidine Impurity 12 (CAS 169506-15-4)
Recommended Standards
- Ethacridine Lactate Impurity 25 (CAS CATO-C4X-260925)
- Tegoprazan impurity 52 (CAS 69829-55-6)
- Ketoprofen Impurity 103 (CAS CATO-C4X-1471103)
- <SC>D</SC>-Sodium 3-hydroxybutyrate-1,3-<SUP>13</SUP>C<SUB>2</SUB> (CAS 1217437-29-0)
- 2-(3-Chlorophenyl)-4-(4-chlorophenyl)-5-methyl-1,2-dihydro-3H-pyrazol-3-one (CAS 303996-82-9)
- Ethoheptazine Hydrochloride (CAS 5982-61-6)
- 3-(3-Hydroxypropyl)-1-(pyrimidin-5-yl)dihydropyrimidine-2,4(1H,3H)-dione (CAS 652993-02-7)
- Ethyl carbamimidothioate (CAS 2986-20-1)
- (1S,3R,4R)-2-(Tert-Butoxycarbonyl)-2-Azabicyclo[2.2.1]Heptane-3-Carboxylic Acid (CAS 291775-53-6)
- Semaglutide impurity 59 (CAS CATO-C4X-222659)
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