Trimetazidine EP Impurity B CAS 1257-19-8
| CAS No. | 1257-19-8 |
| Molecular Formula | C24H34N2O6 |
| Molecular Weight | 446.54 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Trimetazidine EP Impurity B is closely related to a flavonoid core, an amide group, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Trimetazidine EP Impurity B (CAS 1257-19-8, C24H34N2O6) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Trimetazidine EP Impurity B (C24H34N2O6) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Trimetazidine EP Impurity B meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C24H34N2O6 |
| Molecular Weight | 446.54 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Nitrogen Atoms | 2 |
Related Trimetazidine Standards
- Trimetazidine impurity 32 (CAS CATO-C4X-180332)
- Trimetazidine EP Impurity H (CAS 53531-01-4)
- Trimetazidine Impurity 24 (CAS 92432-50-3)
- Trimetazidine Impurity 28 (CAS CATO-C4X-180328)
- Trimetazidine Impurity 29 (CAS CATO-C4X-180329)
- Trimetazidine Impurity 30 (CAS CATO-C4X-180330)
- Trimetazidine Impurity 13 (CAS 92700-82-8)
- Trimetazidine Impurity 18 (CAS CATO-C4X-180318)
Recommended Standards
- Teneligliptin Impurity 54 (CAS CATO-C4X-176054)
- Irbesartan Impurity 4 (CAS CATO-C4X-16664)
- Drotaverin Impurity 79 (CAS CATO-C4X-243579)
- Irbesartan EP Impurity A (CAS 748812-53-5)
- Cefminox Impurity 33 (CAS CATO-C4X-192633)
- Temozolomide Impurity 17 (CAS CATO-C4X-135317)
- Rimegepant Impurity 125 (CAS CATO-C4X-2487125)
- 3-(2-Bromophenyl)-1-(4-(thiophen-3-yl)piperidin-1-yl)propan-1-one (CAS 1797309-65-9)
- 1-(2-Ethyl-3-methyltetrahydropyrimidin-1(2H)-yl)ethanone (CAS 191990-65-5)
- 4-(2-Oxopyrrolidin-1-yl)benzaldehyde (CAS 36151-45-8)
- Ibuprofen EP Impurity N (CAS 3585-52-2)
- 1-(5-methyl-1,2-oxazol-4-yl)ethan-1-ol (CAS 6506-32-7)
- 3-Iodo-1H-indazole-4-carbaldehyde (CAS 944904-44-3)
- C-Type Natriuretic Peptide (32-53) (human, porcine, rat) (CAS 127869-51-6)
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