5-((6-(Piperazin-1-yl)pyrimidin-4-yl)amino)pyrazine-2-carbonitrile CAS 1137475-20-7
| CAS No. | 1137475-20-7 |
| Molecular Formula | C13H14N8 |
| Molecular Weight | 282.30 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
5-((6-(Piperazin-1-yl)pyrimidin-4-yl)amino)pyrazine-2-carbonitrile (CAS 1137475-20-7), molecular formula C13H14N8 and molecular weight 282.30 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 5-((6-(Piperazin-1-yl)pyrimidin-4-yl)amino)pyrazine-2-carbonitrile (C13H14N8) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H14N8 |
| Molecular Weight | 282.30 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Nitrogen Atoms | 8 |
Related Piperazin Standards
- 2-(Piperazin-1-yl)benzo[d]oxazole-5-sulfonamide (CAS 1035840-39-1)
- 5-(Piperazin-1-ylsulfonyl)-1,3-dihydro-2H-benzo[d]imidazol-2-one (CAS 900641-20-5)
- 2-(Piperazin-1-yl)-3-(trifluoromethyl)quinoxaline (CAS 1095706-44-7)
- 4-(Piperazin-1-yl)-2-(trifluoromethyl)quinazoline (CAS 401567-99-5)
- 5-(Piperazin-1-yl)-2-(trifluoromethyl)-1,6-naphthyridine (CAS 890302-17-7)
- (2-Methyl-6-(piperazin-1-yl)pyridin-3-yl)(phenyl)methanone (CAS 1355174-96-7)
- (4-Methyl-6-(piperazin-1-yl)pyridin-3-yl)(phenyl)methanone (CAS 1355182-13-6)
- 5-(Piperazin-1-ylsulfonyl)indolin-2-one (CAS 848369-76-6)
Recommended Standards
- 2,5-Diethoxyterephthalohydrazide (CAS 1136292-71-1)
- 4-(5-(4-Methoxyphenyl)-1,3,4-oxadiazol-2-yl)benzene-1,2-diamine (CAS 1137671-57-8)
- 5-Methyl-6-(4-(4-oxopyridin-1(4H)-yl)phenyl)-4,5-dihydro-1,2,4-triazin-3(2H)-one (CAS 113118-31-3)
- Tert-butyl 4-((2,2,2-trifluoroethyl)amino)piperidine-1-carboxylate (CAS 1146289-88-4)
- Ethyl 8-bromo-6-chloroimidazo[1,2-b]pyridazine-3-carboxylate (CAS 1177415-89-2)
- Ethyl 2-(3,5-difluoro-2-propoxyphenyl)-2-oxoacetate (CAS 1443334-22-2)
- (4-(4-Methoxyphenyl)thiophen-2-yl)boronic acid (CAS 2225176-86-1)
- 1-(2,4-DIchlorophenyl)biguanide hydrochloride (CAS 6634-65-7)
- 2-Chloro-4-nitrobenzonitrile (CAS 28163-00-0)
- N-Methoxycarbonyl Serotonin (CAS 77549-09-8)
- 1-(Bicyclo[2.2.1]Heptan-2-yl)-N-methylethan-1-amine (CAS 1212270-76-2)
- 3,5-Difluorothioanisole (CAS 54378-77-7)
- 2-((1-Benzyl-4-chloro-1H-pyrazol-3-yl)oxy)acetonitrile (CAS 139992-00-0)
- Semaglutide Impurity 115 (CAS CATO-C4X-2226115)
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