Olopatadine Impurity N3 CAS 113835-76-0
| CAS No. | 113835-76-0 |
| Molecular Formula | C21H25NO2 |
| Molecular Weight | 323.43 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Olopatadine Impurity N3 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
CATO supplies Olopatadine Impurity N3 (CAS 113835-76-0), a pharmacopoeial impurity reference standard (molecular formula C21H25NO2, MW 323.43 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Olopatadine Impurity N3 (C21H25NO2) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C21H25NO2 |
| Molecular Weight | 323.43 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Nitrogen Atoms | 1 |
Related Olopatadine Standards
- Olopatadine impurity 146 (CAS CATO-C4X-1135146)
- Olopatadine Impurity 9 (CAS 113835-92-0)
- Olopatadine Impurity 35 (CAS 1376615-97-2)
- Olopatadine Impurity 19 (CAS 55690-15-8)
- Olopatadine lmpurity 61 (CAS CATO-C4X-171862)
- Olopatadine Impurity 47 (CAS 872040-99-8)
- Olopatadine Impurity 11 (CAS 56427-76-0)
- Olopatadine lmpurity 56 (CAS CATO-C4X-171856)
Recommended Standards
- 1-(2-(1-Ethyl-1,2,3,4-tetrahydroquinolin-6-yl)ethyl)-3-phenylurea (CAS 1105239-67-5)
- N-(1-(5-Formylthiophen-2-yl)propan-2-yl)-4-methylbenzenesulfonamide (CAS 1170097-60-5)
- 3-(((5-(Phenylthio)furan-2-yl)methyl)amino)tetrahydrothiophene 1,1-dioxide (CAS 1082821-79-1)
- 9,9-Dibutyl-2-nitro-9H-fluorene (CAS 1194952-33-4)
- Orforglipron Impurity 113 (CAS CATO-C4X-3234113)
- Venetoclax Impurity 135 (CAS CATO-C4X-2495135)
- Pimavanserin impurity 61 (CAS 415950-74-2（free base）)
- 6-Amino-2-(difluoromethyl)-5-iodonicotinic acid (CAS 1806789-57-0)
- 4-{[(difluoromethyl)sulfonyl]methyl}benzoic acid (CAS 1000931-60-1)
- (2R,3R)-1-(2-methoxyethyl)-2-(3-methylthiophen-2-yl)-6-oxopiperidine-3-carboxylic acid (CAS 1212305-26-4)
- 2-Amino-N-hydroxynicotinimidamide (CAS 68640-74-4)
- (2s)-2-Amino-n-(2-methoxyethyl)-4-methylpentanamide hydrochloride (CAS 1423040-71-4)
- 4-(Dimethylamino)butan-2-ol (CAS 5867-64-1)
- Semaglutide-d15 (CAS 910463-68-2(non-labelled))
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