4-((2-Chloro-4-fluorobenzyl)oxy)-3-ethoxybenzoic acid CAS 1142201-95-3
| CAS No. | 1142201-95-3 |
| Molecular Formula | C16H14ClFO4 |
| Molecular Weight | 324.73 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
4-((2-Chloro-4-fluorobenzyl)oxy)-3-ethoxybenzoic acid (CAS 1142201-95-3), molecular formula C16H14ClFO4 and molecular weight 324.73 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 4-((2-Chloro-4-fluorobenzyl)oxy)-3-ethoxybenzoic acid (C16H14ClFO4) is characterized by a flavonoid core, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 4-((2-Chloro-4-fluorobenzyl)oxy)-3-ethoxybenzoic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H14ClFO4 |
| Molecular Weight | 324.73 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | F/Cl-containing |
Related Chloro Standards
- 4-((2-Chloro-4-fluorobenzyl)oxy)-3-methoxybenzohydrazide (CAS 1706445-09-1)
- 3-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(3-methoxypropyl)propanamide (CAS 339099-94-4)
- 4-((2-Chloro-6-fluorobenzyl)oxy)-3-ethoxybenzoic acid (CAS 938375-84-9)
- 5-(3-Chloro-2-fluorobenzyl)-2,4-dimethoxybenzoic Acid (CAS 949465-79-6)
- Methyl 3-(2-chloro-6-fluorophenyl)-5-(2-(dimethylamino)vinyl)isoxazole-4-carboxylate (CAS 338417-50-8)
- (E)-2-((2-chloro-4-fluorobenzylidene)amino)-5-phenylfuran-3-carbonitrile (CAS 478033-32-8)
- (E)-2-((2-chloro-6-fluorobenzylidene)amino)-5-phenylfuran-3-carbonitrile (CAS 478033-38-4)
- 2-(8-Chloro-1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7h-purin-7-yl)ethane-1-sulfonyl fluoride (CAS 877964-18-6)
Recommended Standards
- Dihydralazine Impurity 6 (CAS CATO-C4X-20786)
- Methyl (E)-3-(2-chloro-6-fluorophenyl)-5-(2-(dimethylamino)vinyl)isoxazole-4-carboxylate (CAS 1391943-72-8)
- Hydrochlorothiazide Impurity 55 (CAS CATO-C4X-117755)
- Ethyl 7-chloro-1-ethyl-6-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylate (CAS 70186-33-3)
- 1-Chloro-4-(difluoromethoxy)-2,3,5,6-tetrafluoro-benzene (CAS 1214357-98-8)
- 7-Bromo-1-methoxyisoquinoline (CAS 1374258-30-6)
- 8-Bromo-4-chromanone (CAS 204377-88-8)
- (R)-1-cyclohexyl-2-methylpiperazine (CAS 1134675-36-7)
- 4-(Difluoromethyl)-6-(trifluoromethyl)picolinic acid (CAS 1804716-86-6)
- Methyl 3-azabicyclo[3.2.1]octane-8-carboxylate (CAS 1363381-33-2)
- N-((2,4-difluorophenyl)carbamothioyl)benzamide (CAS 887266-92-4)
- Tert-butyl (3S)-4-cyano-3-fluoropiperidine-1-carboxylate (CAS 2103132-18-7)
- 3-(Bicyclo[2.2.1]hept-5-en-2-yl)acrylic acid (CAS 15222-64-7)
- Semaglutide impurity 202 (CAS CATO-C4X-2226202)
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