Sofosbuvir Impurity 12 CAS 114262-49-6
| CAS No. | 114262-49-6 |
| Molecular Formula | C10H16N2O6 |
| Molecular Weight | 260.24 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Sofosbuvir Impurity 12 (CAS 114262-49-6), a pharmacopoeial impurity reference standard (molecular formula C10H16N2O6, MW 260.24 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Sofosbuvir Impurity 12 (C10H16N2O6) is characterized by an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Sofosbuvir Impurity 12 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H16N2O6 |
| Molecular Weight | 260.24 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Nitrogen Atoms | 2 |
Related Sofosbuvir Standards
- Sofosbuvir Impurity 12 (CAS 2041584-99-8)
- Sofosbuvir Impurity 13 (CAS CATO-C4X-105213)
- Sofosbuvir Impurity 14 (CAS CATO-C4X-105214)
- Sofosbuvir Impurity 15 (CAS CATO-C4X-105215)
- Sofosbuvir Impurity 16 (CAS CATO-C4X-105216)
- Sofosbuvir Impurity 17 (CAS CATO-C4X-105217)
- Sofosbuvir Impurity 18 (CAS CATO-C4X-105218)
- Sofosbuvir Impurity 19 (CAS 1946820-96-7)
Recommended Standards
- 4,9-Dimethoxy-6-methyl-8H-furo[2,3-g]chromen-8-one (CAS 114191-63-8)
- 5-(4-formylphenoxymethyl)-3-methylfuran-2-carboxylic acid (CAS 1153306-99-0)
- 6-(Trifluoromethyl)benzo[b]thiophene-2-carbohydrazide (CAS 1135282-94-8)
- Ethyl (E)-3-oxo-2-(3-oxoisobenzofuran-1(3H)-ylidene)butanoate (CAS 1164509-62-9)
- Cefprozil Impurity 51 (CAS CATO-C4X-149251)
- Argatroban Impurity 101 (CAS CATO-C4X-1007101)
- Benzocaine EP Impurity H (CAS 619-45-4)
- Trans-3-fluoro-5,6-dihydroquinoline-5,6-diol (CAS 148324-56-5)
- 1-Bromo-3-fluoro-5-(2-methylpropoxy)benzene (CAS 1309933-41-2)
- 1-(4,5-Dimethylthiazol-2-yl)ethan-1-one (CAS 7531-76-2)
- MK-4074 (CAS 1039758-22-9)
- 1-Acetyl-N-(3-methylbutyl)piperidin-4-amine (CAS 1119452-89-9)
- N-[4-(5-Cyano-1H-1,2,3-triazol-4-yl)phenyl]acetamide (CAS 39807-69-7)
- Semaglutide Impurity 133 (CAS CATO-C4X-2226133)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com