Benzocaine EP Impurity H CAS 619-45-4
| CAS No. | 619-45-4 |
| Molecular Formula | C8H9NO2 |
| Molecular Weight | 151.16 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Structurally, Benzocaine EP Impurity H (C8H9NO2) contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 5.0, corresponding to approximately 5 ring(s) or double-bond equivalent(s). With a molecular weight of 151.16 g/mol, it falls into the medium-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a process- or degradation-related impurity, Benzocaine EP Impurity H (CAS 619-45-4, C8H9NO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Benzocaine EP Impurity H meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H9NO2 |
| Molecular Weight | 151.16 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Nitrogen Atoms | 1 |
Related Benzocaine Standards
- Benzocaine EP Impurity G (CAS 150-13-0)
- Benzocaine EP Impurity D (CAS 1333-08-0)
- Benzocaine EP Impurity C (CAS 582-33-2)
- Benzocaine-13C6 (CAS 1391054-61-7)
- Benzocaine EP Impurity A (CAS 623-04-1)
- Benzocaine EP Impurity F (CAS 1877-77-6)
- Benzocaine impurity 32 (CAS 5338-44-3)
- Benzocaine Impurity 31 (CAS 71134-95-7)
Recommended Standards
- Mefenamic Acid Impurity 3 (CAS 83-41-0)
- Ethacridine Lactate Impurity 17 (CAS 3420-97-1)
- Neostigmine Impurity 21 (CAS 3958-86-9)
- Pyridoxine Impurity 7 (CAS 205321-07-9)
- CAS 2452301-13-0 (CAS 2452301-13-0)
- Erlotinib Impurity 18 (CAS 1683583-37-0)
- Cephacetrile Impurity 3 (CAS CATO-C4X-23113)
- Parecoxib Impurity 44 (CAS 2338845-31-9)
- 1,3-Dibromo-2,4-difluoro-5-(trifluoromethoxy)benzene (CAS 1806327-32-1)
- 898754-26-2 3-(2,6-Dimethylphenyl)-1-(2-methylphenyl)propan-1-one DTXSID90644770 (CAS 898754-26-2)
- 2-(1,4-Diazepan-1-yl)benzonitrile (CAS 1020986-79-1)
- 2-Chloro-4-methoxypyridine hydrochloride (CAS 1951441-96-5)
- 2-Amino-6-benzyl-7-methyl-5-oxo-4-phenyl-5,6-dihydro-4H-pyrano[3,2-c]pyridine-3-carbonitrile (CAS 265315-64-8)
- Semaglutide impurity 261 (CAS CATO-C4X-2226261)
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