3-Methoxy-5-(trifluoromethyl)benzene-1-sulfonyl chloride CAS 1146355-33-0
| CAS No. | 1146355-33-0 |
| Molecular Formula | C8H6ClF3O3S |
| Molecular Weight | 274.64 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 3-Methoxy-5-(trifluoromethyl)benzene-1-sulfonyl chloride.
3-Methoxy-5-(trifluoromethyl)benzene-1-sulfonyl chloride (CAS 1146355-33-0) is a high-purity analytical reference standard with the molecular formula C8H6ClF3O3S and a molecular weight of 274.64 g/mol.
3-Methoxy-5-(trifluoromethyl)benzene-1-sulfonyl chloride (C8H6ClF3O3S) contains a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 3-Methoxy-5-(trifluoromethyl)benzene-1-sulfonyl chloride meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H6ClF3O3S |
| Molecular Weight | 274.64 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | F/Cl-containing |
| Sulfur Atoms | 1 |
Related Methoxy Standards
- 2-Methoxy-4-(trifluoromethyl)-benzenesulfonyl chloride (CAS 145980-59-2)
- 2-Methoxy-5-(trifluoromethyl)benzenesulfonyl chloride (CAS 612541-12-5)
- 4-Methoxy-2-(trifluoromethyl)benzenesulfonyl chloride (CAS 775288-85-2)
- 4-Methoxy-3-(trifluoromethyl)benzenesulfonyl chloride (CAS 694514-21-1)
- 4-Methoxy-3-(1,3,4-oxadiazol-2-yl)benzenesulfonyl chloride (CAS 1384430-05-0)
- 4-Methoxy-N,N-diisopropyl Tryptamine (CAS 1135694-32-4)
- 5-Methoxy-N,N-dipropyltryptamine (CAS 69496-75-9)
- (5-Methoxy-1H-indol-3-yl)(piperidin-1-yl)methanethione (CAS 937604-38-1)
Recommended Standards
- 4'-Chloro-4-fluoro-3-(trifluoromethyl)-1,1'-biphenyl (CAS 1032506-90-3)
- (2-(Trifluoromethoxy)phenyl)methanesulfonyl chloride (CAS 116827-38-4)
- 5-Chloro-1-phenyl-3-(trifluoromethyl)pyrazole-4-carbaldehyde (CAS 318288-78-7)
- 4-Chloro-4'-fluoro-2-(trifluoromethyl)-1,1'-biphenyl (CAS 1214334-97-0)
- Ubrogepant N-Oxide 2 (CAS CATO-C4X-34027)
- 1,4-Dibromo-2-difluoromethoxy-5-(trifluoromethylthio)benzene (CAS 1803835-13-3)
- 4-(N-ethyl-N-cyanoethyl)amino-2-methylbenzaldehyde (CAS 119-97-1)
- Methyl 5-(chlorosulfonyl)-2,3-dihydro-1H-indene-2-carboxylate (CAS 600166-73-2)
- 2-Bromo-5-(3,3,3-trifluoropropoxy)pyridine (CAS 1620691-18-0)
- Pyrimidine, 2-chloro-4-(3,4-dimethoxyphenyl)-5-fluoro- (CAS 1494526-17-8)
- 3-Nitro-N-(piperidin-3-yl)pyridin-2-amine hydrochloride (CAS 1185307-69-0)
- N-(2-Methoxyethyl)-5-(N-(thiophen-2-ylmethyl)sulfamoyl)furan-2-carboxamide (CAS 1172557-14-0)
- 5-Aminopiperidin-2-one Hydrochloride (CAS 1235440-18-2)
- Liraglutide(14-22)TFA Salt (CAS CATO-C4X-199212)
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