4-Methoxy-2-(trifluoromethyl)benzenesulfonyl chloride CAS 775288-85-2
| CAS No. | 775288-85-2 |
| Molecular Formula | C8H6ClF3O3S |
| Molecular Weight | 274.64 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 274.64 g/mol gives 4-Methoxy-2-(trifluoromethyl)benzenesulfonyl chloride distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
4-Methoxy-2-(trifluoromethyl)benzenesulfonyl chloride (CAS 775288-85-2) is a high-purity analytical reference standard with the molecular formula C8H6ClF3O3S and a molecular weight of 274.64 g/mol.
4-Methoxy-2-(trifluoromethyl)benzenesulfonyl chloride (C8H6ClF3O3S) contains a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H6ClF3O3S |
| Molecular Weight | 274.64 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Halogen Content | F/Cl-containing |
| Sulfur Atoms | 1 |
Related Methoxy Standards
- 3-Methoxy-5-(trifluoromethyl)benzene-1-sulfonyl chloride (CAS 1146355-33-0)
- 2-Methoxy-4-(trifluoromethyl)-benzenesulfonyl chloride (CAS 145980-59-2)
- 2-Methoxy-5-(trifluoromethyl)benzenesulfonyl chloride (CAS 612541-12-5)
- 4-Methoxy-3-(trifluoromethyl)benzenesulfonyl chloride (CAS 694514-21-1)
- 4-Methoxy-3-(1,3,4-oxadiazol-2-yl)benzenesulfonyl chloride (CAS 1384430-05-0)
- 4-Methoxy-N,N-diisopropyl Tryptamine (CAS 1135694-32-4)
- 5-Methoxy-N,N-dipropyltryptamine (CAS 69496-75-9)
- (5-Methoxy-1H-indol-3-yl)(piperidin-1-yl)methanethione (CAS 937604-38-1)
Recommended Standards
- 4-(Trifluoromethoxy)phenylmethanesulfonyl chloride (CAS 683813-55-0)
- 4-(2,2,2-Trifluoroethoxy)benzene-1-sulfonyl chloride (CAS 954369-08-5)
- 5-OH-imidacloprid-13C-15N2 (CAS CATO-CCPD102480)
- 2-Methyl-4-(trifluoromethoxy)benzenesulfonyl chloride (CAS 376637-84-2)
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- 2-(4-Cyclohexylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 820223-94-7)
- 5-Amino-2H-benzo[b][1,4]oxazin-3(4H)-one (CAS 148890-63-5)
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- 2-Cyclopropylpyridin-4-amine (CAS 340006-71-5)
- tert-Butyl N-methyl-N-[(3S)-pyrrolidin-3-yl]carbamate hydrochloride (CAS 1788058-40-1)
- 3-(2-Amino-ethoxymethyl)-pyrrolidine-1-carboxylic acid tert-butyl ester (CAS 1353946-60-7)
- 2,2,2-Trifluoro-1-(furan-2-yl)ethan-1-amine hydrochloride (CAS 65686-91-1)
- 2,4-Dimethylbenzophenone (CAS 1140-14-3)
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