2-chloro-4-ethynylthiophene CAS 1148049-36-8
| CAS No. | 1148049-36-8 |
| Molecular Formula | C6H7ClS |
| Molecular Weight | 146.64 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
2-chloro-4-ethynylthiophene (C6H7ClS) contains sulfur-containing functionality, chlorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
2-chloro-4-ethynylthiophene (CAS 1148049-36-8), molecular formula C6H7ClS and molecular weight 146.64 g/mol, is a CATO reference standard with documented purity and traceability.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6H7ClS |
| Molecular Weight | 146.64 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | Cl-containing |
| Sulfur Atoms | 1 |
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Recommended Standards
- 4-(chloromethyl)-2-methylthiophene (CAS 1082602-29-6)
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- 2-(1-Chloroethyl)thiophene (CAS 28612-98-8)
- 4'-(Trifluoromethyl)-[1,1'-biphenyl]-3-carbaldehyde (CAS 343604-24-0)
- 5-((Dimethylamino)methyl)thiazol-2-amine (CAS 948572-68-7)
- 1-(4-(1-Aminoethyl)phenyl)ethan-1-one (CAS 318969-15-2)
- 5(S),6(R)-DiHETE (CAS 82948-88-7)
- 1-(4-(Aminomethyl)piperidin-1-yl)hexan-1-one hydrochloride (CAS 1606936-59-7)
- N-Methyl-1-(1,4,5-trimethyl-1H-imidazol-2-yl)methanamine dihydrochloride (CAS 920478-94-0)
- (4R,6S)-6-((2-Allyl-6-(3-(4-fluorophenoxy)propyl)-4-methylphenoxy)methyl)-4-((tert-butyldiphenylsilyl)oxy)tetrahydro-2H-pyran-2-one (CAS 1080028-75-6)
- 3-(4-Phenoxybenzoyl)-3-azabicyclo[3.1.0]hexane-2-carboxylic acid (CAS 1009674-13-8)
- 1-(4-Methoxy-naphthalen-1-yl)-ethylaminehydrochloride (CAS 1071572-54-7)
- Semaglutide impurity 103 (CAS 1446013-07-5)
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