(2R,3R,5S)-2-(6-Amino-2-iodo-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3-ol CAS 115044-77-4
| CAS No. | 115044-77-4 |
| Molecular Formula | C10H12IN5O3 |
| Molecular Weight | 377.14 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
(2R,3R,5S)-2-(6-Amino-2-iodo-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3-ol (CAS 115044-77-4), molecular formula C10H12IN5O3 and molecular weight 377.14 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of (2R,3R,5S)-2-(6-Amino-2-iodo-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3-ol (C10H12IN5O3) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, iodine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H12IN5O3 |
| Molecular Weight | 377.14 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | I-containing |
| Nitrogen Atoms | 5 |
Recommended Standards
- Benzyl 2-bromo-6-fluoro-3-(trifluoromethyl)benzoate (CAS 2271443-04-8)
- (2R,3S,5R)-5-(6-Amino-2-iodo-9H-purin-9-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol (CAS 118706-49-3)
- (S)-2-(4-Iodobenzamido)pentanedioic acid (CAS 38974-68-4)
- (2R,3S,5R)-5-(4-Amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol (CAS 187479-00-1)
- methyl 3-(methylsulfanyl)butanoate (CAS 207983-28-6)
- 2-Amino-2-(5-bromo-1H-indol-3-yl)acetic acid (CAS 1270311-06-2)
- 4-(3,4-Difluorophenyl)pyrimidin-2-amine (CAS 1248370-53-7)
- 2-[(4-chlorophenyl)methyl]cyclopentan-1-one (CAS 2866-68-4)
- 2,3-Dihydroimidazo[1,2-a]pyridine-2-carboxylic acid (CAS 108128-81-0)
- (3aS,4S,6aS)-2,2-dimethyl-4-((trityloxy)methyl)-4,6a-dihydro-3aH-cyclopenta[d][1,3]dioxol-4-ol (CAS 681854-00-2)
- 3-Bromotetrahydro-2H-thiopyran 1-oxide (CAS 332041-59-5)
- Cyclic N-Acetyl-D-mannosamine (CAS 7772-94-3)
- 6-Chloro-N-(2,4-dichlorophenyl)-2H-chromene-3-carboxamide (CAS 338761-06-1)
- Endo-Gly29-Tirzepatide (CAS CATO-CPTD788685)
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