Meclizine Impurity N1 DiHCl CAS 115291-60-6
| CAS No. | 115291-60-6 |
| Molecular Formula | C25H27ClN2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Meclizine Impurity N1 DiHCl (C25H27ClN2HCl) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Meclizine Impurity N1 DiHCl (CAS 115291-60-6) is a certified pharmaceutical impurity reference standard with the molecular formula C25H27ClN2HCl and a molecular weight of 427.41 g/mol.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C25H27ClN2 2*HCl |
| Molecular Weight | 427.41 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Meclizine Standards
- Meclizine Dihydrochloride (CAS 1104-22-9)
- Meclizine N-Oxide (CAS 114624-69-0)
- Meclizine N,N'-Dioxide (CAS 114624-70-3)
- Meclizine-d8 Dihydrochloride (CAS 1246816-06-7)
- Meclizine-d8 DiHCl (CAS 1432062-16-2)
- Meclizine Impurity 14 (CAS 299460-62-1)
- Meclizine Dihydrochloride Monohydrate (CAS 31884-77-2)
- Meclizine Hydrochloride (CAS 410538-37-3)
Recommended Standards
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- N-Cyclopropyl-2-(1-methylpyrazol-4-yl)cyclopropan-1-amine (CAS 1934677-45-8)
- Clevidipine Impurity 31 (CAS 1207068-16-3)
- 1-tert-butyl-1H-1,2,4-triazole-3-carboxylic acid (CAS 1803599-66-7)
- 2-Chloro-7-methoxybenzo[d]thiazole (CAS 1175277-80-1)
- N-Acetyl-S-(2-cyanoethyl)-L-cysteine-d3 Ammonium Salt (CAS CATO-CCAD302161)
- 2-(6-Aminopyridin-2-yl)ethan-1-ol (CAS 101012-00-4)
- 3X Flag Peptide trifluoroacetate salt (CAS 402750-12-3)
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