Milnacipran impurity 30 CAS 115373-42-7
| CAS No. | 115373-42-7 |
| Molecular Formula | C11H10ClN |
| Molecular Weight | 191.66 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Milnacipran impurity 30 (CAS 115373-42-7, C11H10ClN) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Milnacipran impurity 30 (C11H10ClN) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H10ClN |
| Molecular Weight | 191.66 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Milnacipran Standards
- Milnacipran Impurity 16 (CAS 871100-19-5)
- Milnacipran Impurity 5 (CAS 1932365-99-5)
- Milnacipran Impurity N11 (CAS CATO-CP150468)
- Milnacipran Impurity 1 (CAS 66823-04-9)
- Milnacipran Impurity 13 (CAS 19532-98-0)
- Milnacipran impurity 34 (CAS CATO-C4X-103334)
- Milnacipran impurity 37 (CAS 96847-51-7)
- Milnacipran Impurity 4 (CAS 64805-64-7)
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