6-((Trifluoromethyl)thio)pyridin-3-amine CAS 1153767-25-9
| CAS No. | 1153767-25-9 |
| Molecular Formula | C6H5F3N2S |
| Molecular Weight | 194.18 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 6-((Trifluoromethyl)thio)pyridin-3-amine (C6H5F3N2S) is characterized by a nitrile group, sulfur-containing functionality, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
CATO supplies 6-((Trifluoromethyl)thio)pyridin-3-amine (CAS 1153767-25-9), a certified reference material (molecular formula C6H5F3N2S, MW 194.18 g/mol) for analytical method development and quality control.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6H5F3N2S |
| Molecular Weight | 194.18 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Trifluoromethyl Standards
- 4-((Trifluoromethyl)thio)pyridin-3-amine (CAS 1153766-90-5)
- 2-((Trifluoromethyl)thio)pyridin-3-amine (CAS 1153767-00-0)
- 5-((Trifluoromethyl)thio)pyridin-2-amine (CAS 1153767-57-7)
- 3-((Trifluoromethyl)thio)pyridin-2-amine (CAS 1204234-81-0)
- 3-((Trifluoromethyl)thio)pyridin-4-amine (CAS 1204235-21-1)
- 2-(Trifluoromethyl)-5,6-dihydro-4H-pyrrolo[3,4-d]thiazole (CAS 1245915-62-1)
- 5-(Trifluoromethyl)thiophene-2-carboximidamide (CAS 1260663-11-3)
- 5-((Trifluoromethyl)thio)pyridin-3-amine (CAS 1935597-56-0)
Recommended Standards
- 7-Methoxy-2,3-dihydrobenzo[b][1,4]dioxine-6-carbaldehyde (CAS 116757-66-5)
- 3-(2-Methoxy-2-oxoethyl)benzoic acid (CAS 113496-14-3)
- 4-Methoxycarbonyl-3-methyl-benzoicacid (CAS 116934-87-3)
- 3-Methyl-4-oxo-4,5,6,7-tetrahydro-1-benzofuran-2-carboxylic acid (CAS 112579-43-8)
- 1-(2-(Cyclopropylamino)-4-methylthiazol-5-yl)ethanone (CAS 866769-76-8)
- (4-Methyl-3-oxo-1-phenylpyrazolidin-4-yl)methyl acetate (CAS 80336-03-4)
- 1-methyl-3-phenyl-4,5,6,7-tetrahydro-1h-pyrazolo[4,3-c]pyridine (CAS 87642-36-2)
- Chloro(tetrahydrothiophene)gold(I) (CAS 39929-21-0)
- (R)-1-(3,4-dichlorophenyl)pentan-1-amine (CAS 1213477-84-9)
- N-(4-fluorobutyl)thietan-3-amine (CAS 1849198-98-6)
- 7-bromo-5-fluoro-1H-benzimidazole-4-carbonitrile (CAS 1807698-29-8)
- 3-(2-Chloro-4-pyridinyl)-1,2,4-thiadiazol-5-amine (CAS 1236970-11-8)
- 727-45-7 11b-Methyl-1,2,5,6,11,11b-hexahydro-3H-indolizino[8,7-b]indol-3-one MFCD00698933 (CAS 727-45-7)
- Semaglutide Impurity 145 (CAS CATO-C4X-2226145)
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