Methyl (3-(2-chloro-6-fluorophenyl)acryloyl)glycinate CAS 1158108-32-7
| CAS No. | 1158108-32-7 |
| Molecular Formula | C12H11ClFNO3 |
| Molecular Weight | 271.67 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Methyl (3-(2-chloro-6-fluorophenyl)acryloyl)glycinate.
Methyl (3-(2-chloro-6-fluorophenyl)acryloyl)glycinate (CAS 1158108-32-7) is a high-purity analytical reference standard with the molecular formula C12H11ClFNO3 and a molecular weight of 271.67 g/mol.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, Methyl (3-(2-chloro-6-fluorophenyl)acryloyl)glycinate is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 271.67 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), Methyl (3-(2-chloro-6-fluorophenyl)acryloyl)glycinate meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H11ClFNO3 |
| Molecular Weight | 271.67 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Methyl Standards
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- 2-Chloro-2'-(trifluoromethyl)-[1,1'-biphenyl]-3-amine (CAS 1261739-69-8)
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Recommended Standards
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- tert-Butyl ((1H-1,2,4-triazol-5-yl)methyl)carbamate (CAS 311349-66-3)
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- 4-Acetyl-1-ethyl-3,5-dimethyl-1H-pyrrole-2-carboxylic acid (CAS 1707370-30-6)
- N-(5,6-dihydro-4H-cyclopenta[d]thiazol-2-yl)benzamide (CAS 600129-09-7)
- Semaglutide impurity 57 (CAS 2773558-06-6)
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