Amitriptyline EP Impurity D CAS 1159-03-1
| CAS No. | 1159-03-1 |
| Molecular Formula | C20H25NO |
| Molecular Weight | 295.42 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Amitriptyline EP Impurity D is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Amitriptyline EP Impurity D (CAS 1159-03-1, C20H25NO) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Amitriptyline EP Impurity D (C20H25NO) contains a steroid core, an amide group, a hydroxyl group, an ether linkage. Its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Amitriptyline EP Impurity D under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C20H25NO |
| Molecular Weight | 295.42 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Nitrogen Atoms | 1 |
Related Amitriptyline Standards
- Amitriptyline Hydroxy Impurity F (CAS 64520-05-4)
- Amitriptyline EP Impurity F (CAS 1159-82-6)
- Amitriptyline (CAS 50-48-6)
- Amitriptyline EP Impurity C (CAS 72-69-5)
- Amitriptyline EP Impurity A (CAS 1210-35-1)
- Amitriptyline Hydrochloride - Impurity F (Oxalate Salt) (CAS 1246833-15-7)
- Amitriptyline-13C3 Hydrochloride (CAS 1329837-86-6)
- Amitriptyline N-Oxide Hydrochloride (CAS 4290-60-2)
Recommended Standards
- Melitracen Impurity 15 (CAS CATO-C4X-120215)
- Cloperastine Impurity 2 (CAS 4960-10-5)
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- Efinaconazole Impurity 30 (CAS 124627-86-7)
- Difelikefalin Impurity 46 (CAS 1021171-64-1)
- Trospium Impurity 8 (CAS CATO-C4X-20388)
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Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com