Ethyl 6-methylquinazoline-2-carboxylate CAS 1159976-37-0
| CAS No. | 1159976-37-0 |
| Molecular Formula | C12H12N2O2 |
| Molecular Weight | 216.24 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Ethyl 6-methylquinazoline-2-carboxylate (C12H12N2O2) is characterized by an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Ethyl 6-methylquinazoline-2-carboxylate (CAS 1159976-37-0) is a high-purity analytical reference standard with the molecular formula C12H12N2O2 and a molecular weight of 216.24 g/mol.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H12N2O2 |
| Molecular Weight | 216.24 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Nitrogen Atoms | 2 |
Related Ethyl Standards
- 3-Methylquinazoline-2,4(1H,3H)-dithione (CAS 16081-92-8)
- 2-Methylquinazoline-4-carboxylic acid (CAS 7671-97-8)
- 2-Methylquinazoline-6-carboxylic acid (CAS 648423-83-0)
- 2-Methylquinazoline-4-carboxamide (CAS 7671-94-5)
- 1-methylquinazoline-2,4-dione (CAS 604-50-2)
- 6-Methylquinazoline-2,4(1H,3H)-dione (CAS 62484-16-6)
- 8-Methylquinazoline-2,4(1H,3H)-dione (CAS 67449-23-4)
- 2-Methylquinazoline-4-thiol (CAS 6484-28-2)
Recommended Standards
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- 5-benzyl-1-methyl-1H-pyrazole-4-carboxylic acid (CAS 116344-33-3)
- 5-((4-Bromo-3-nitro-1h-pyrazol-1-yl)methyl)-3-isopropyl-1,2,4-oxadiazole (CAS 1252469-94-5)
- N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-1H-pyrazole-3-carboxamide (CAS 379255-85-3)
- 4-Cyclopropoxy-N-methylpyridine-3,5-dicarboxamide (CAS 1243318-46-8)
- 2-(4-Chloro-2-methyl-1H-indol-3-yl)ethan-1-amine (CAS 1018592-90-9)
- 1,4-Dimethyl-1,4-diazabicyclo[2.2.2]octane-1,4-diiumiodide (CAS 14870-72-5)
- 3-Methoxy-4-thiomorpholin-4-ylcyclobut-3-ene-1,2-dione (CAS 1858251-77-0)
- 1-Isopropyl-2-Methyl-Cyclohexene (1-Menthene) (CAS 15582-48-6)
- 1'-Benzyl-6-bromospiro[indoline-3,4'-piperidin]-2-one (CAS 1258638-01-5)
- methyl 3-(4-bromophenyl)butanoate (CAS 1021735-42-1)
- Semaglutide Impurity 152 xTFA (CAS CATO-C4X-2226152)
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