Ziprasidone EP Impurity B CAS 1159977-56-6
| CAS No. | 1159977-56-6 |
| Molecular Formula | C21H19ClN4O2S |
| Molecular Weight | 426.92 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Ziprasidone EP Impurity B (CAS 1159977-56-6, C21H19ClN4O2S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C21H19ClN4O2S, Ziprasidone EP Impurity B contains a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 426.92 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C21H19ClN4O2S |
| Molecular Weight | 426.92 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
| Sulfur Atoms | 1 |
Related Ziprasidone Standards
- Ziprasidone Impurity 24 (CAS 884305-07-1)
- Ziprasidone Impurity 11 (CAS 188797-76-4)
- Ziprasidone Impurity 12 (CAS 884305-08-2)
- Ziprasidone Impurity 30 (CAS 188797-80-0)
- Ziprasidone Impurity 59 (CAS CATO-C4X-124059)
- Ziprasidone EP Impurity C (CAS 1159977-64-6)
- Ziprasidone-d8 (CAS 1126745-58-1)
- Ziprasidone Impurity 4 (CAS 1797879-13-0)
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- 5-Bromo-4-iodo-1H-pyrazole-3-carboxylic acid (CAS 1934264-98-8)
- 5-Thien-2-yl-2H-tetrazole (CAS 59541-58-1)
- 5-(4-Chlorophenyl)-N-cyclopropyl-1-(2,5-dichlorophenyl)-1H-pyrazole-3-carboxamide (CAS 477712-36-0)
- 4-(4-Nitrophenoxy)tetrahydro-2H-pyran (CAS 886851-40-7)
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