Fosfomycin Open Ring Impurity A CAS 1160525-87-0

Purity 97%+In StockPharmacopoeial Impurity Standards
CAS No.1160525-87-0
Molecular FormulaC3H9O5P
Molecular WeightN/A
CategoryPharmacopoeial Impurity Standards / EP Impurities
AvailabilityIn Stock

Chemical Structure

Fosfomycin Open Ring Impurity A CAS 1160525-87-0 chemical structure

Description

This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.

Fosfomycin Open Ring Impurity A (CAS 1160525-87-0) is a certified pharmaceutical impurity reference standard with the molecular formula C3H9O5P:xNH3 and a molecular weight of 173.11 g/mol.

The molecular framework of Fosfomycin Open Ring Impurity A (C3H9O5P:xNH3) is characterized by an amide group, a phosphate ester group, a carboxylic acid group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

Molecular FormulaC3H9O5P : xNH3
Molecular Weight173.11 g/mol
Purity97%+
StorageStore at 2-8°C, protect from light, keep sealed and dry
Solubility (reference)Soluble in methanol, ethanol, DMSO, water
StabilityLight-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening
Degree of Unsaturation (DBE)-1.5
CAS Registry Year (est.)1989
Nitrogen Atoms1

Related Fosfomycin Standards

Recommended Standards

Why CATO?