2-(p-Tolyl)-6-(trifluoromethyl)-4,5-dihydropyridazin-3(2H)-one CAS 1161004-75-6

Description

Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2-(p-Tolyl)-6-(trifluoromethyl)-4,5-dihydropyridazin-3(2H)-one.

2-(p-Tolyl)-6-(trifluoromethyl)-4,5-dihydropyridazin-3(2H)-one (CAS 1161004-75-6) is a high-purity analytical reference standard with the molecular formula C12H11F3N2O and a molecular weight of 256.22 g/mol.

The molecular framework of 2-(p-Tolyl)-6-(trifluoromethyl)-4,5-dihydropyridazin-3(2H)-one (C12H11F3N2O) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

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