3-(4-Chlorophenyl)-3-(4-hydroxyphenyl)isobenzofuran-1(3H)-one CAS 116143-36-3
| CAS No. | 116143-36-3 |
| Molecular Formula | C20H13ClO3 |
| Molecular Weight | 336.77 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
3-(4-Chlorophenyl)-3-(4-hydroxyphenyl)isobenzofuran-1(3H)-one (CAS 116143-36-3), molecular formula C20H13ClO3 and molecular weight 336.77 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a steroid core, a hydroxyl group, an ether linkage, chlorine substitution, 3-(4-Chlorophenyl)-3-(4-hydroxyphenyl)isobenzofuran-1(3H)-one is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 336.77 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 3-(4-Chlorophenyl)-3-(4-hydroxyphenyl)isobenzofuran-1(3H)-one under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C20H13ClO3 |
| Molecular Weight | 336.77 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | Cl-containing |
Related Chlorophenyl Standards
- 3-(4-Chlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione (CAS 125313-99-7)
- 2-((4-Chlorophenyl)sulfonyl)-3-((3-fluorophenyl)amino)prop-2-enenitrile (CAS 882255-74-5)
- 4-((5-(3-Chlorophenyl)furan-2-yl)methyl)phthalazin-1(2H)-one (CAS 338785-55-0)
- 4-((5-(4-Chlorophenyl)furan-2-yl)methyl)phthalazin-1(2H)-one (CAS 338785-51-6)
- 4-(4-Chlorophenyl)-2-(4-methoxyphenoxy)pyridine-3-carbonitrile (CAS 339103-71-8)
- 4-{[5-(2-chlorophenyl)furan-2-yl]methyl}-1,2-dihydrophthalazin-1-one (CAS 338785-59-4)
- 5-(3-Chlorophenyl)-2-(2-methoxyphenoxy)pyridine-3-carbonitrile (CAS 338964-18-4)
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Recommended Standards
- Ethyl 6-amino-2-(chloromethyl)-5-cyano-4-(1-ethyl-1H-pyrazol-4-yl)-4H-pyran-3-carboxylate (CAS 1005611-67-5)
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- N-(5-Chloro-2-methoxyphenyl)-2-(3-(3-methyl-1,2,4-oxadiazol-5-yl)azetidin-1-yl)acetamide (CAS 1327541-32-1)
- (5-((4-Chlorobenzyl)thio)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)methanol (CAS 318469-47-5)
- 3-(Thiophen-2-yl)-1-(p-tolyl)-1H-pyrazole-5-carboxylic acid (CAS 618382-78-8)
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- 2-Methoxy-O-methyltyrosine (CAS 91248-17-8)
- n-(3-Methylbutan-2-ylidene)hydroxylamine (CAS 600-20-4)
- 1,1'-(3-Oxopyrazolidine-1,2-diyl)diethanone (CAS 161799-96-8)
- 1,5-Dichloro-2-iodo-4-methoxybenzene (CAS 189138-40-7)
- 1,8-Dihydro-1-(phenylmethyl)cyclohepta[b]phosphole (CAS 83998-97-4)
- 4-(3-Bromo-2-oxopropyl)phenyl acetate (CAS 56071-69-3)
- Palbociclib Impurity 187 (CAS CATO-C4X-1125187)
- MOTS-c Peptide (CAS 1627580-64-6)
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